ESTRO 2023 - Abstract Book

S1005

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ESTRO 2023

The patients treated in 2018 with the VMAT technique had less acute toxicities compared to the patients treated in 2011 with 3D-CRT. In addition, the late overall toxicity was lower, and the late cosmetic results were better in 2018 patient group treated with the VMAT technique than the 2011 patient group treated with 3D-CRT.

References:

[1] Virén T, Heikkilä J, Myllyoja K, Koskela K, Lahtinen T, Seppälä J. Tangential volumetric modulated arc therapy technique for left-sided breast cancer radiotherapy. Radiat Oncol. 2015 Apr 8;10:79.

PO-1256 Reduced cardiovascular events incidence in breast cancer patients treated with radiotherapy

E. Otero Pla 1 , N. Jornet Sala 2 , M.J. Fuentes Raspall 1 , S.J. Rabi Mitre 1 , J. Isern Verdum 1 , A. Pedro Olivé 1 , J.V. Rojas Cordero 1 , S. Bermejo Martínez 3 , F. Surinach Pérez 3 , G. Sancho Pardo 1 1 Hospital Santa Creu i Sant Pau, Radiation Oncology, Barcelona, Spain; 2 Hospital Santa Creu i Sant Pau, Medical Physics, Barcelona, Spain; 3 Hospital Santa Creu i Sant Pau, Radiation Therapy Technician, Barcelona, Spain Purpose or Objective To investigate the association of mean heart dose (MHD) and cardiac complications in breast cancer (BC) radiotherapy (RT) and the impact of using the deep inspiration breath hold (DIBH) technique. Materials and Methods We analysed the RedCap Database for patients with BC treated with RT from 2013 to 2021. Information about cardiac events was obtained from the medical records. The majority of patients were treated with normofractionation. We investigated the association of dose, cardiovascular risk factors, systemic treatment, and RT technique. The statistical analysis was made with the SPSS Software and R statistics. We have performed bivariate analysis, for non-parametric variables with the U-Mann Whitney test and parametric with the T-test, which was used to evaluate the association of cardiac events and MHD. Results A cohort of 873 patients, 460 right-side and 413 left-side. Mean age: 61 years. The MHD for the left-side was 5.48Gy, and for the right-side 1.65Gy (p<0.001). We detected a difference between 3DCRT versus IMRT on MHD with a 1.15Gy increase on IMRT (p<0.001). The MHD was significantly reduced by DIBH (n= 179) from 7.13 Gy to 3.32 Gy (p<0.001). Median follow up of 4.52 years and overall survival of 93%. 30 from 873 (0.7% right, 2.2% left) patients had cardiac complications (Table 1). None of those patients was treated in DIBH. The MHD was significantly higher than the MHD of women without cardiac events (6.7 Gy vs 3.4 Gy; p=<0.001).

Conclusion DIBH technique for breast is effective in reducing MHD and may contribute to reducing the incidence of cardiac complications in patients with breast cancer radiotherapy.

PO-1257 Axillary lymph nodes incidental dose with standard 3D-CRT: a retrospective evaluation

M. Borgia 1 , C. Rosa 1 , F.C. Di Guglielmo 1 , L.A. Ursini 1 , M. Nuzzo 1 , L. Caravatta 1 , D. Genovesi 1

1 "SS Annunziata" Hospital, "G. D'Annunzio" University, Radiation Oncology Unit, Chieti, Italy