ESTRO 2023 - Abstract Book

S1011

Digital Posters

ESTRO 2023

In patients with positive IMN, 100 % of tumors had contact with IMPV: In 36 cases (83.7%) to a main branch and in 7 cases (16.3%) to IMPV side branches. In patients without pathological IMN on the other hand, still in 81.4 % of cases the tumor had contact to IMPV, however only in 13 patients (30.2 %) there was contact between tumor and IMPV main branches.

PO-1265 Quality of life in hypofractionated versus normofractionated radiotherapy for breast cancer

M. Bohli 1 , M. Elbessi 1 , Z. Naimi 1 , R. Ben Amor 1 , D. Aissaoui 1 , L. Kochbati 1

1 Abderrahmen Mami hospital, Radiotherapy, Ariana, Tunisia

Purpose or Objective the aim of our study was to compare the quality of life (QoL) among breast cancer patients undergoing hypofractionated or normofractionated radiotherapy (RT) after breast conservative surgery (BCS). Materials and Methods Eighty-seven patients treated with BCS followed by adjuvant RT from august 2017 to July 2020 were included. Fifty-one patients (59%) received hypofractionated RT (HFRT) 40Gy/15fraction/3weeks followed by a boost of 13.35Gy/5fractions. Thirty-six patients (41%) received normofractionated RT(NFRT) 50Gy/25fraction/5weeks followed by a boost of 16Gy/8fractions. The health related QoL was assessed after 31 months median time from completion of RT using two validated EORTC questionnaires: QLQ-C30 and the breast cancer module QLQ-Br23. QLQ-C30 questionnaire consists of a global quality of life scale, five functional scales (physical, role, emotional, cognitive and social) and nine symptom scales (fatigue, nausea and vomiting, pain, dyspnea, insomnia, appetite loss, constipation, diarrhea and financial difficulties).The QLQ-BR23 questionnaire assesses four functional domains (body image, future perspective, sexual enjoymentand sexual functioning) and four symptoms (upset by hair loss, systemic therapy side effects, arm symptoms and breast symptoms). Scores relative to both questionnaires were calculated according to the EORTC recommendations. High scores in functional scales and low scores in the symptom scales indicate a greater functioning and a better QoL. Statistical analysis was done with SPSS v 21 and p-value < 0.05 was considered as significant Results The global health status was 68.9 for patients treated with HFRT and 65 for patients treated with NFRT (p=0.43). Average scores, in the HFRT vs NFRT group, for physical, role, emotional, cognitive and social function were: 74.1% vs 77.4% (p=0.44), 84.6% vs 81.5% (p=0.54), 63.1% vs 59.6% (p=0.56), 76.8% vs 63% (p=0.02) and 81% vs 78.7% (p=0.69) respectively. There was no difference in the symptom scales between the two groups. The difference was significant for the financial difficulties favoring HFRT: 25.5% vs 43.5% for NFRT (p=0.02). Patients in both groups had a positive body image, 85.3 in HFRT vs 80.9 in NFRT (p=0.38). The perspective score was 42.86 vs 46.1 (p=0.70) in HFRT and NFRT respectively. The scores for breast symptoms and arm symptoms in the HFRT and NFRT groups were 28.9 vs 31.5 (p=0.62) and 38.3 vs 37.8 (p=0.93) respectively Conclusion Hypofractionation had a significant positive impact on financial difficulties. The scores were 25.5 for HFRT vs 43.5 for NFRT (p=0.02). With regards to the other subscales of the questionnaires no significant difference between the two groups was encountered.Our results are encouraging to adopt HFRT regimen as the standard in the context of limited access to RT facilities and economic difficulties L.F. Cazzaniga 1 , L. Maffioletti 1 , E. Vitali 1 , S. Vukcaj 1 , F. Piccoli 1 , R. Muni 1 , F.R. Filippone 1 , M. Motta 1 , A. Paludetti 2 , E. Mauri 3 , L. Burgoa 2 , C. Valerii 2 , F. Palamara 4 , A. Aluffi 2 , P. Porsio 2 , P. Fenaroli 2 1 ASST Papa Giovanni XXIII, Radiotherapy, Bergamo, Italy; 2 ASST Papa Giovanni XXIII, Breast Surgery, Bergamo, Italy; 3 ASST papa Giovanni XXIII, Breast Surgery, Bergamo, Italy; 4 ASST Papa Giovcanni XXIII, Breast Surgery, Bergamo, Italy Purpose or Objective Intraoperative radiotherapy (IORT) has been proposed as alternative to external beam in early breast cancer, however previous studies suggest that patient selection must be improved in order to reduce the rate of ipsilateral breast tumour recurrence (IBRFS). In 2006 our centre started a non randomised study authorized by Lombard Aldermanship and approved by the local ethics committee. Materials and Methods 917 IORT have been performed between 2006 and 2020 on 897 patients (median age 64 years; range 35-88), 20 of them had bilateral IORT (synchronous or metachronous). Patients inclusion/exclusion criteria were: Age > 48 years old (if postmenopausal); clinical, mammography/ultrasound diagnostic of unifocal invasive carcinoma, ultrasound major diameter < 2.5 cm. Informed consent was mandatory. In the first 5 years there were 41 major protocol violations due the age or the nodule , enclosed in the analysis. Recently published guidelines suggest more stringent eligibility criteria for IORT: age ≥ 50, favourable histologies, unifocality, ER+, pN0, grade 1-2, tumour < 2 cm, Luminal A, non triple negative. PO-1266 Very stringent selection criteria are needed for intraoperative radiotherapy in early breast cancer