ESTRO 2023 - Abstract Book

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ESTRO 2023

detect the amount of blood in the sample. Through a series of computer vision techniques, it was possible to extract the vascularized regions, which are represented as red color on top of the skin's structure. General recommendations and a specific hypoallergenic restorative cream were provided to the participants daily use during the RT and for least one month after. Results OCT imaging detected a statistically significant increase in inflammation at the end of RT compared to the skin changes for each patient for the irradiated vs. non irradiated breast (p <0.05), and showed decrease in erythema at 3 months (p 0.032) in the irradiated breast (Figure 1). OCT showed quantitative differences with different fractions schemes, with higher intensity changes in vascularization and erythema at 25 fraction regime (Figure 2) The overall tolerance was good, with no differences between groups i.e 30.8% didn’t show radiodermitis, 64.1% radiodermitis G1 and 5.1% G2. The impact on patients' quality of life was low with a total of 53.08% of patients have EORTC QLQ-C30 > 80, and 38.46% between 50 to 80. Figure 1: Clinical and OCT imaging in baseline (t0), and the end of RT (tF) and at 3 months (t+3)

Figure2: Intensity changes in vascularization in irradiated breast measured by OCT scanning in baseline (t0), and the end of RT (tF) and at 3 months (t+3)

Conclusion OCT imaging could detect and quantify the effects on microvasculature caused by RT and could represent an advance in the standardization of changes in WBRT. These preliminary results will allow for the design of protocols for measuring and comparing the degree of radiodermitis and the potential benefits of adjuvant therapies.

PO-1281 External validation of the MSKCC nomogram for Ductal Carcinoma in Situ and risk factors analysis

G. Oses 1 , E. Mensión 2 , C. Pomarola 2 , H. Castillo 2 , F. León 1 , I. Torras 2 , I. Cebrecos 2 , X. Caparrós 2 , S. Ganau 3 , B. Ubeda 3 , X. Bargalló 3 , B. González-Farre 4 , E. Sanfeliu 4 , S. Vidal 5 , M. Mollà 1 1 Hospital Clínic of Barcelona, Radiation Oncology, Barcelona, Spain; 2 Hospital Clínic of Barcelona, Obstetrics and Gynecology, Barcelona, Spain; 3 Hospital Clínic of Barcelona, Radiology, Barcelona, Spain; 4 Hospital Clínic of Barcelona, Pathological Anatomy, Barcelona, Spain; 5 Hospital Clínic of Barcelona, Nuclear Medicine, Barcelona, Spain Purpose or Objective Adjuvant radiotherapy and hormonotherapy after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) to prevent local relapse are considered standard of care. To predict the risk of ipsilateral breast tumor relapse (IBTR) after BCS, the Memorial Sloan-Kettering Cancer Center (MSKCC) developed a nomogram. The aim of this study was to evaluate risk factors of local recurrence (LR) in a Spanish cohort and to assess external validation of the MSKCC nomogram. Materials and Methods A retrospective analysis was carried out between 1999 and 2019, 296 patients were treated for DCIS at the Hospital Clínic of Barcelona. Eighty-nine (30%) patients treated with mastectomy were excluded from the analysis. The following risk

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