ESTRO 2023 - Abstract Book

S1078

Digital Posters

ESTRO 2023

Conclusion IMRT and HT provide similar dose constraints achieved to the lungs when compared to 3DCRT planning but with a significant increase in the low dose volume. Higher dose volumes are observed in increasing length of PTV in all three techniques. Upper third esophageal lesions in IMRT and HT have lesser low dose irradiation. However, randomized studies with a larger sample size and follow up of the patients are required to identify long term clinical effects and outcomes.

PO-1346 Chemoradiation versus chemotherapy alone in locally advanced biliary cancer. A meta-analysis.

S. Bisello 1 , C. Malizia 2 , A. Benini 3 , F. Mammini 3 , V. Laghi 3 , S. Paolinelli 3 , A. Guido 4 , A. Galuppi 4 , A. Arcelli 5 , M. Ferioli 1 , M. Buwenge 3 , G. Macchia 6 , F. Deodato 6 , S. Cilla 7 , S. Cammelli 8 , A.G. Morganti 1 1 Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 2 Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, , Bologna, Italy; 3 Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES , Alma Mater Studiorum University of Bologna, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy; 4 Radiation Oncology , IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5 Radiation Oncology , IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 6 Radiation Oncology Unit , Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, Italy; 7 Medical Physics Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso , Italy; 8 Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES , Alma Mater Studiorum University of Bologna, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy Purpose or Objective Biliary tract cancers (BTC) are rare and aggressive neoplasms. Based on international guidelines the standard treatment of locally advanced or unresectable BTC is chemotherapy (CHT) alone. Chemoradiation (CRT) may represent an alternative treatment. Aim of this study is to analyse the available comparisons between combined CRT or CHT alone for primary or recurrent unresectable BTC. Materials and Methods Papers were searched on PubMed, Scopus, and Cochrane Library. Prospective or retrospective trials reporting a comparison between concurrent CRT or CHT alone for unresectable non-metastatic, primary or recurrent BTC were included. Only English-written papers, published from January 2010 to June 2022 were considered. Results Four papers were included in the analysis, with a total of 1578 patients with locally advanced BTC treated with concurrent CRT, and 4521 treated with CHT alone. Three studies included only patients with intrahepatic BTC, while one series included only patients with gallbladder cancer.