ESTRO 2023 - Abstract Book

S1169

Digital Posters

ESTRO 2023

Conclusion Despite the small sample , as showed in a respective Polish study on 358 patients, our analysis seems to suggest that combined ratios of blood cells could have prognostic implications with the perspective of increasing personalized therapies for glioma patients.

PO-1444 Dynamic neutrophil-to-lymphocyte ratio - a new predictive biomarker for recurrent sarcomas?

C. Martinez 1 , F. Cury 1 , C. Freeman 1 , R. Asso 1 , N. Rastogi 2

1 McGill University Health Centre, Radiation Oncology, Montreal, Canada; 2 McGill University, Faculty of Medicine and Health Sciences, Montreal, Canada Purpose or Objective The neutrophil-to-lymphocyte ratio (NLR) is an accessible measure of systemic inflammation known to have a prognostic value across different cancers. In sarcomas, NLR has been mainly studied as a prognostic marker of response to chemotherapy and targeted therapy. Our study aims to determine if dynamic changes in NLR from diagnosis and throughout radiation therapy (RT) treatment are associated with the time of recurrence. Here we sought to determine the value of NLR as an independent predictive and prognostic biomarker in adult soft tissue sarcomas (STS). Materials and Methods We conducted a retrospective analysis for recurrent sarcomas (RS) and a paired number of non-recurrent sarcoma (NRS) patients, treated between 2013 and 2022. Clinical and demographic data were collected, including radiation therapy treatments, and complete blood count (CBC). NLR was calculated by dividing the absolute neutrophils by absolute lymphocytes. The NLR was calculated for RS at 4-time points: diagnosis, post-radiation therapy (RT), recurrence, and after a second-RT treatment. For NRS the NLR was calculated at diagnosis and post-RT. We used correlation analyses, t-test and simple proportions for data analyses. Results We identified 28 patients that presented with one or more recurrences. Of all patients, 9 had available CBCs results at the 4 selected time points. RS numbers were compared with 9 NRS patients. The median age at diagnosis for NRS was 67.3