ESTRO 2023 - Abstract Book

S1185

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ESTRO 2023

A subset of PCa patients receiving SRT with concomitant bicalutamide will experience changes in bowel habits and urinary function resulting in “moderate to big problems”. Furthermore, a considerable number of patients will experience sexual dissatisfaction, but without significant relation to SRT. These observations could be used to improve patients’ involvement in shared decision-making as well as rehabilitation after SRT.

PO-1463 1.5T MR-guided SBRT for Oligometastatic Prostate Cancer: Toxicity and Clinical Outcomes

D. Poon 1 , J. Yuan 2 , B. Yang 3 , O.L. Wong 4 , S.T. Chiu 5 , G. Chiu 5 , K.Y. Cheung 3 , S.K. Yu 3

1 Hong Kong Sanatorium & Hospital, Comprehensive Oncology Centre, Happy Valley, Hong Kong (SAR) China; 2 Hong Kong Sanatorium & Hospital, Research department, Happy Valley, Hong Kong (SAR) China; 3 Hong Kong Sanatorium & Hospital, Medical Physics Department, Happy Valley, Hong Kong (SAR) China; 4 Hong Kong Sanatorium & Hospital, Research Department, Happy Valley, Hong Kong (SAR) China; 5 Hong Kong Sanatorium & Hospital, Department of Radiotherapy, Happy Valley, Hong Kong (SAR) China Purpose or Objective To prospectively report toxicities and preliminary clinical outcomes of 1.5Tesla (T) MR-guided stereotactic body radiotherapy (MRgSBRT) in patients (pts) with oligometastatic prostate cancer (OMPC). Materials and Methods During Apr 2020-Sep 2022, 56 consecutive metastatic PC pts underwent online adaptive MRgSBRT on a 1.5T MR-LINAC plus androgen deprivation therapy (ADT) with or without additional systemic treatments. MRgSBRT was delivered in five fractions (2 fractions/week) of 7.25-8 Gy/fraction to metastases, and of 6.7-8 Gy/fraction to primary/recurrent prostate tumor with daily online adaptation. An isotropic CTV-PTV margin of 5 mm (but 3mm in primary posterior) was applied. Patients were followed and PSA levels were monitored at 1 mo(nth) and then every 3 months. Prostate-specific membrane antigen (PSMA) PET scans were arranged if continuous PSA progressions and/or clinical symptoms were encountered. Toxicities were assessed using the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Overall survival, radiographic progression free survival (rPFS) (by PSMA-PET), and biochemical PFS (bPFS) were estimated using Kaplan-Meier (KM) method. Lesion based local control (LC) rate was also reported. Results 34 (de-novo, n=28; recurrent, n=1; induced, n=5) OMPC pts (median age: 66.5y) with a median 14.2mo FU (3.4mo-29.4mo) were finally included (Table 1). Among them, 27 and 25 pts received ADT only and additional systemic therapy, respectively. All MRgSBRT fractions were successfully delivered with a median duration of 70 minutes (range: 46-104 minutes). Adapt to-position (ATP) and adapt-to-shape (ATS) were conducted in 120 (71%) and 50 (29%) fractions. In total, 31 primary/recurrent prostate lesions, 47 metastatic lymph nodes (LN), and 29 metastatic bones were irradiated. Characteristics of pts, planning, and treatment were shown in Table 1. Encouraging clinical outcomes were achieved. All pts remained alive during FU. Regarding toxicities, only 3 G2 (1 fatigue; 2 dysuria) in 3 pts but no ≥ G3 events were reported. All but 3 bone targets (in 1 pt) responded to treatment and achieved the lesion-based LC rate of 97.2% (104/107) according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Four pts showed new metastatic lesions on PSMA-PET. PSA was well controlled in 29 pts and progressed (nadir+2ng/ml) in 5 pts. The estimated OS, rPFS and bPFS at 29-mo were 100% (95%CI: 100%-100%), 81% (95%CI: 65%-100%), and 78% (95%CI: 61%-99%), respectively, as shown in Figure 1.