ESTRO 2023 - Abstract Book
S1203
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ESTRO 2023
Variable
Median [interquartile range] or N (%)
Age (years)
72 [66-76]
PSA at diagnosis (ng/mL)
10.83 [6.7-22]
Baseline IPSS NCCN risk Low Intermediate High Staging Conventional* PSMA PET-CT Planning image CT MRI-CT fusion
8 [5-15]
22 (12.87) 69 (40.35) 77 (45.03)
115 (67.25) 45 (26.32)
20 (11.70) 137 (80.12) Overall treatment time (days) 11 [10-13] Androgen deprivation therapy No 6 months 12 months 18-36 months 59 (12.87) 54 (31.58) 2 (1.75) 68 (39.77)
Acute urinary toxicity 0 1 2 3 4-5
61 (35.67) 84 (49.12) 15 (8.77) 2 (1.17) 0 (0) 101 (59.06) 46 (26.90) 12 (7.02) 4 (2.34) 0 (0) 67 (39.18) 17 (9.94) 11 (6.43)
Acute gastrointestinal toxicity 0 1 2 3 4-5
Late urinary toxicity 0 1 2 3 4 5
1 (0.58) 1 (0.58) 0 (0)
Late gastrointestinal toxicity 0 1 2 3 4-5 6 (3.51) 1 (0.58) 0 (0) * Conventional: CT scan +/- bone scintigraphy 72 (42.11) 18 (10.53)
Conclusion CBCT guided SBRT is a safe treatment option, permitting a high dose delivery with excellent acute and late toxicity profiles. Efficacy results will be reported once appropriate follow up is reached.
PO-1485 1.5T MR-guided daily adaptive radiotherapy: preliminary clinical report of the first 5000 fractions
M. Rigo 1 , N. Giaj-Levra 1 , R. Mazzola 1 , L. Nicosia 1 , F. Ricchetti 1 , E. Pastorello 1 , P. Ravelli 1 , A. De Simone 1 , D. Gurrera 1 , S. Naccarato 1 , G. Sicignano 1 , R. Ruggieri 1 , F. Alongi 1
1 IRCCS Sacro Cuore Don Calabria Hospital, Advanced Radiation Oncology Department, Negrar di Valpolicella (VR), Italy
Purpose or Objective 1.5T MR-linac improves target volume and adjacent OARs visualization, ensuring high precision in radiation treatment delivery. Daily MR-imaging allows on-table adapted planning and real-time intra-fraction imaging without additional exposure to radiation. Our department implemented the first high field MRgRT system in Italy and herein we present the preliminary report of the first 5000 fractions delivered. We aim to describe the clinical implementation, feasibility, toxicity and patient tolerability of daily adapted RT.
Materials and Methods
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