ESTRO 2023 - Abstract Book

S1270

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ESTRO 2023

Conclusion Our study showed that surgical excision combined with adjuvant RT is an excellent option, with good results assessed both by the patients and the clinicians, although their perspectives regarding results might differ. We also reported a very low recurrence rate, although a longer patient follow-up is required.

PO-1565 Hyperthermia in combination with radiotherapy and chemotherapy in tissue sarcomas of trunk and limbs

P. trecca 1 , M. Fiore 2 , G. D'Ercole 3 , G.M. Petrianni 3 , P. Falco 3 , C. Greco 3 , E. Ippolito 4 , S. Valeri 5 , B. Vincenzi 6 , S. Ramella 3

1 Campus Bio-Medico University Of Rome, Radiation Oncology, Rome, Italy; 2 Campus Bio-Medico University of Rome, Radiation Oncology, rome, Italy; 3 Campus Bio-Medico University of Rome, Radiation Oncology, Rome, Italy; 4 Ippolito, Radiation Oncology, Rome, Italy; 5 Campus Bio-Medico University of Rome, Surgery, Rome, Italy; 6 Campus Bio-Medico University of Rome, Medical Oncology, Rome, Italy Purpose or Objective The aim of the study is to analyze toxicity and efficacy of addition of HyperThermia (HT) to both radiotherapy (RT) and chemotherapy (CT) in patients affected by Soft Tissue Sarcomas (STS) localized to the trunk and limbs. Materials and Methods We retrospectively investigated 21 patients (10 males and 11 females, all with Performance Status ECOG 0-1), affected by STS treated with HT combined with RT and/or CT. The mean age was 61 years (range, 43-87). HT session was performed immediately after RT and within three hours from the administration of chemotherapy. The duration of each HT session varied from 70 to 90 minutes to guarantee that target temperature was greater than 40 ° for at least 60 minutes. BSD-500 or BSD-2000 system were used depending on depth of lesion. Three patients had stage I-II disease, 16 ( patients III A/B disease and 2 stage IV for concomitant lung metastases. In 10 patients the lesion treated was the primary tumor and in 11 a relapse of the disease. The mean target was 8.8 cm (range 1-20 cm). HT was associated to RT in 9 patients, to radiochemotherapy (gemcitabine-based) in 6 patients, to CT in one patient. 5 patients underwent CT (anthracycline and ifofosfamide) following by RT and HT. In 16 patients, the intent of treatment was neoadjuvant, in 2 postoperative after incomplete resection and in 3 cases for unresectable disease. Mean radiation dose was 52 Gy (range 48-60 Gy). Results The most represented histology was pleomorphic undifferentiated sarcoma.

19 patients were treated with superficial HT and 2 with deep HT.

No skin toxicity greater than grade 2 was detected and only one patient had hematological toxicity greater than grade 3. Among 16 patients treated with neoadjuvant purpose 13 underwent surgery and 3 are going to be evaluated for surgery.

In all 13 cases R0 resection was obtained and in 5 cases (38.5%) a complete pathological response was reported.