ESTRO 2023 - Abstract Book

S1722

Digital Posters

ESTRO 2023

Conclusion IMPT significantly reduces the dose to the hippocampi for patients with pituitary adenomas when compared to coplanar and non-coplanar FSRT. This may result in a significant reduction of long-term toxicity such as cognitive decline. References 1. Minniti G et al. Pituitary. 2018;21(2):154-161

2. Combs SE et al. Radiother Oncol. 2021 Mar;156:80-94. 3. Eekers DB et al. Radiother Oncol. 2018 Jul;128(1):37-43. 4. Lambrecht et al. Radiother Oncol. 2018 Jul;128(1):26-36.

PO-1960 A novel approach to nano- and microdosimetric simulations for proton therapy

K. Ytre-Hauge 1 , E. Folkedal 1 , C. Stokkevåg 1,2 , H. Henjum 1 , E. Lyngholm 1 , A. Tefre Samnøy 2

1 University of Bergen, Department of Physics and Technology, Bergen, Norway; 2 Haukeland University Hospital, Department of Oncology and Medical Physics, Bergen, Norway Purpose or Objective Microdosimetric quantities such as the lineal energy ( y ) accounts for the stochastic nature of energy deposition and is related to the biological effectiveness of protons. y depends on both proton energy and site , but the most relevant sites for variations in proton biological effectiveness are still unknown and broad in silico investigations at nano- and micrometer level are extremely computationally demanding. To provide a basis for further radiobiological research in proton therapy we developed a new Monte Carlo (MC) based methodology to efficiently obtain y distribution over the relevant range of proton energies and site sizes.

Materials and Methods