ESTRO 2023 - Abstract Book


Saturday 13 May

ESTRO 2023

During treatment delivery, CINE MV images were recorded at every fraction for the medial and lateral tangential primary field. On the final frame of each CINE MV recording the chest wall was matched with the Digital Reconstructed Radiograph (DRR) from the planning CT scan, resulting in two observations of the chest wall positional error per fraction. The match was performed at the chest wall level closest to the IMN target. The geometrical errors were rounded to integer millimeters and binned. For each 1 mm bin a new treatment plan was recalculated assuming that the error observed in the 2D CINE MV image was caused by a vertical chest wall shift in the IMN region. This allowed for a weighted plan sum recalculation of the delivered V90_CTVn_IMN. The primary outcome was the difference between delivered and planned V90_CTVn_IMN. Results In total, 39 breast cancer patients, 37 females, were included for analysis. The median age was 59 years (range 27-86). Mastectomy and breast conserving therapy was performed in 21 and 18 patients, respectively. Twenty-seven patients were treated with 40Gy/15fx and 12 patients with 50Gy/25fx. Simultaneous integrated boost was given to 8 patients. The mean number of CINE MV observations per patient was 36 (range 26-55). Most patients (67%) had on average a lowered chest wall position on CINE MV images compared to the plan, which is shown as worse IMN coverage in figure 1 . This translated into a statistically significant reduction of the delivered mean V90_CTVn_IMN of 1.54 % (95% CI, 0.59-2.48; p=0.002) compared to the planned dose. The V90_CTVn_IMN reduction was >3 % in six patients and >9 % in three patients, figure 2 . The delivered mean lung dose was reduced by 0.28% (95% CI, 0.09-0.46; p=0.004) compared to the planned dose. The mean heart dose was 1.4 Gy, both delivered and planned.

Conclusion Using CINE MV images, we found that the delivered V90_CTVn_IMN was significantly lower than planned. In 8 % of the patients the V90_CTVn_IMN reduction exceeded 9 %. No clinically relevant differences were found for the mean lung dose or mean heart dose. Based on these data our institution expects to implement cone beam CT as daily image guided RT in high-risk breast cancer patients.

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