ESTRO 2023 - Abstract Book

S377

Sunday 14 May 2023

ESTRO 2023

Moreover, Compared to RTOG-0617, patients in the REQUITE (OR=0.19, p<0.0001) and Spanish cohorts (OR=0.48, p=0.01) had a lower risk of developing acute G3+ esophageal toxicity (C-index: 77%; Figure 1A & B). Esophageal V35Gy remained a significant predictor of acute G3+ esophageal toxicity following all 5 sensitivity analyses. Prediction and discrimination of the model were best when the CONVERT trial dataset was removed (C-index: 80%; Figure 1B & 1C). Rerunning the analyses using mean dose (OR=1.09, p<0.0001) instead of V35Gy for all cohorts removing CONVERT yielded similar results (C-index: 79%). Results using physical dose and EQD2,10 were comparable.