ESTRO 2023 - Abstract Book

S446

Sunday 14 May 2023

ESTRO 2023

The symptoms and function scores showed the deterioration of all reported functions (e.g., swallowing, speech, mouth opening) during the period of treatment (Figure 2). Most of the functions recovered within six months and showed further improvement compared to pre-treatment. Only two symptoms, dry mouth and sticky saliva persisted for more than one year compared to baseline.

Conclusion This study revealed that within six months after the proton therapy, most of the negative influence subsided and showed an improvement in functions compared to pre-treatment. Although some symptoms lasted longer than one year, this was not seen in the reported global health status and utility values. A larger patient group and comparison to patients receiving photon treatment will be performed.

Poster Discussion: Urology

PD-0565 Outcomes of the use of partial boost in radical radiotherapy in muscle invasive bladder cancer. I. Navarro 1 , S. Arulanantham 1 , Z. Liu 2 , M. Tjong 1 , V. Kong 1 , V. Malkov 1 , T. Tadic 1 , N. Fleshner 3 , G. Kulkarni 3 , A. Zlotta 4 , C. Catton 5 , A. Berlin 1 , S. Sridhar 6 , D.(. Jiang 6 , P. Chung 1 , S. Raman 1 1 Princess Margaret Cancer Centre, Radiation Oncology, Toronto, Canada; 2 Princess Margaret Cancer Centre, Department of Biostatistics, Toronto, Canada; 3 Princess Margaret Cancer Centre, Surgical Oncology, Toronto, Canada; 4 Princess Margaret Cancer Centre , Surgical Oncology , Toronto, Canada; 5 Princess Margaret Cancer Centre , Radiation Oncology , Toronto, Canada; 6 Princess Margaret Cancer Centre, Medical Oncology, Toronto, Canada Purpose or Objective Radical radiation treatment (RT) to the bladder is an alternative to the cystectomy for select patients with muscle invasive bladder cancer (MIBC); however, there is limited data on dose-painted RT. We report the outcomes of a partial boost RT technique in MIBC. Materials and Methods This was a single institution retrospective study of 117 cT2-4N0M0 MIBC patients treated with external beam RT (EBRT) to the bladder, and sequential or concomitant boost to the tumor bed after maximal transurethral resection of bladder tumor