ESTRO 2023 - Abstract Book

S547

Sunday 14 May 2023

ESTRO 2023

Conclusion Conclusions: According to our experience, SABR for patients with spinal metastases was useful to improve pain control. Regarding different survival outcomes, an adequate selection of patients and radiation dose is essential to propose this ablative approach. PD-0656 Evaluation of an interactive, multi-language, neurocognitive app in CNS radiation oncology R. Kotecha 1 , T. Kutuk 1 , M. Rubens 2 , A. Balda 1 , Y. Odia 3 , M. Hall 1 , S. Ramos 1 , M. Ramirez 1 , A. Mohler 3 , M. McDermott 4 , M. Ahluwalia 5 , M. Mehta 1 1 Miami Cancer Institute, Baptist Health South Florida, Radiation Oncology, Miami, USA; 2 Miami Cancer Institute, Baptist Health South Florida, Office of Clinical Research, Miami, USA; 3 Miami Cancer Institute, Baptist Health South Florida, Neuro-Oncology, Miami, USA; 4 Miami Neuroscience Institute, Baptist Health South Florida, Neurosurgery, Miami, USA; 5 Miami Cancer Institute, Baptist Health South Florida, Medical Oncology, Miami, USA Purpose or Objective Neurocognitive decline following radiotherapy for CNS malignancies significantly affects functional status and clinical outcomes. Yet, conventional in-person neuropsychological tests are time-consuming and have had limited penetration into practice. The objective of this study was to implement an app-based solution, facilitating management of multiple patients simultaneously with several domains tested along temporal assessments and being suitable for cross-cultural use in multiple languages. Materials and Methods Patients undergoing radiotherapy for CNS malignancies from December 2021 to September 2022 who enrolled onto a single institution prospective clinical trial (NCT05504681) using an app-based neurocognitive evaluation program were analyzed. The interactive app-based assessment consisted of 5 domains in 6 languages: learning and memory (Hopkins verbal learning test-revised [HVLT-R]), attention and processing speed (Digit symbols modalities test [SDMT]), verbal fluency (Controlled oral word association test [COWAT]), and executive function (Trail making test [TMT]). Patients underwent neurocognitive evaluation prior to treatment as well as with routine imaging and clinical follow-up, typically at 3-month intervals. In order to evaluate the program’s functionality and usefulness, participants completed a patient feedback survey after at least 2 assessments. Reliable change index (RCI) was analyzed at 3- and 6-month assessments compared to baseline.