ESTRO 2023 - Abstract Book

S936

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ESTRO 2023

Conclusion Preliminary results from this novel protocol on MR-ART for patients with gastric lymphoma show large improvements in target coverage with similar doses to organs at risk for patients treated with MR-ART relative to the predicted plan with no adaption. Treatment planning, daily recontouring, reoptimization of the plan, tracking and gating, and treatment delivery on the MR-linac were feasible, and further analysis will be performed when more patients have been accrued.

PO-1171 Reduced Intensity conditioning followed by allo-HSCT in patients with refractory/relapsing lymphomas

S. Saldi 1 , F. Camilli 2 , A. Guerini 3 , A. Carotti 4 , A. Pierini 5 , V. Bini 6 , S. Magrini 3 , M. Buglione 3 , C. Aristei 7

1 Santa Maria della Misericordia Hospital, Department of Radiation Oncology, Perugia, Italy; 2 University of Perugia, Department of Radiation Oncology, Perugia, Italy; 3 University of Brescia and Spedali Civili Hospital, Department of Radiation Oncology, Istituto del Radio O. Alberti, Brescia, Italy; 4 Santa Maria della Misericordia Hospital, Department of Haematology, Perugia, Italy; 5 Santa Maria della Misericordia Hospital and University of Perugia, Department of Haematology, Perugia, Italy; 6 University of Perugia and Santa Maria della Misericordia Hospital, Department of Medicine, Section of Internal Medicine, Endocrinology & Metabolism, Perugia, Italy; 7 University of Perugia and Santa Maria della Misericordia Hospital, Department of Radiation Oncology, Perugia, Italy Purpose or Objective Since standard high-dose chemotherapy followed by autologous haematopoietic stem cell transplantation (HSCT) often fails in patients with lymphomas, allogeneic HSCT (allo-HSCT) with reduced intensity conditioning (RIC) has emerged as a feasible salvage strategy. It administer fludarabine, cyclophosphamide and low-dose total body irradiation (TBI) and exerts its action through an immunosuppressive effects RIC was reported to lower transplant-related mortality in most series of