ESTRO 2023 - Abstract Book

S951

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ESTRO 2023

According to the greater Casablanca cancer registry 2017, specific incidences of nasopharyngeal cancer (NPC) were higher for women between 60 and 64 years old, and men between 55 and 59 years old. Our study aimed to report clinical and therapeutic characteristics of patients who had NPC depending on their age, and to evaluate the impact of age on the treatment and prognosis of NPC Materials and Methods it’s a retrospective study that included patients who had NPC treated by radiotherapy +/-chemotherapy between April 2017 and October 2020 in our department. Using the medical database of included patients, we gathered their medical history, received treatment, toxicities and therapeutic results. Patients were divided into two groups: less than50 years old(group 1) and more than 50 years old(group 2). The statistical analysis was done using SPPS in its version 21 Results 153 patients were included: 91 patients in the first group and 62 patients in the second one. More comorbidities were found in older patients (22.6% vs6.6%, p=0.013). We noticed that 73.6% of young patients vs67.7% of the older ones had a locally advanced cancer ( ≥ Stade III). One patient had a stage I disease (group1). Induction chemotherapy was administered for 76.9% of first group's patients vs 50% of the second group (p=0.001). Regarding the concomitant treatment, 21% of older patients received carboplatine vs12% of the younger patients. During the course of radiotherapy, a break in treatment was more frequently reported in the second group (21% vs 17.6%). A definitive stop before the end of treatment was noted for one patient of the first group vs 5 patients of the second one. Hospitalization for a mean period of 4 days due to a major toxicity was required for 12.9% of older patients vs 4.3% of the younger ones. Compliance in follow-up was better in group 1(79.1% vs 59.6%, p= 0.009). Mortality was significantly higher in group 2(24.2% vs 9.9%, p=0.05) and was mostly due to a progression of the disease. Among older patients who died due to a progression of their cancer, 40% needed neoadjuvant treatment and didn’t receive it because of an expected poor tolerance after geriatric evaluation. Complete response was obtained for 72.6% of old patients and 75.8% of young patients. After a follow-up of 2 years, an OS of 44.1 months (CI95%[41.747-46.545]) was found in the first group vs an OS of 37.7 months (CI95%[33.275-42.296]) in the second one(p=0.012) (figure 1) . The median of survival couldn’t be measured as we had a survival rate exceeding 50% in both groups

Conclusion our study reflects the frequent late diagnosis in our context. Frequent comorbidities in old patients compromise the course of treatment and result in poorer tolerance, which significantly impacts the prognosis of the cancer. In our study, we found that the age of patients had a significant impact on the prognosis of NPC during a 2-year follow-up, therefore we recommend a closer surveillance of older patients during the course of treatment.

PO-1189 A retrospective review: risk factors associated with osteoradionecrosis in Head and Neck cancer

T. O'Donovan 1 , K. Fitzgerald 2 , D.C. Lyons 2 , D.A. England 1 , P.M. McEntee 1 , A. Devine 1 , P.A. Barry 1,1 , D.E. O' Sullivan 3

1 University College Cork, Medical Imaging and Radiation Therapy, Co. Cork, Ireland; 2 Cork University Hospital, Radiation Oncology, Co. Cork, Ireland; 3 Cork University Dental School & Hospital, Dental School, Co. Cork, Ireland Purpose or Objective Osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) in patients with head and neck cancer (HNC). This study aimed to investigate potential precipitating factors that may contribute to the development of ORN to aid in the identification of potential targets for prevention. Materials and Methods Ethical approval was obtained from the local Clinical Research Ethics Committee (CREC). A database of 1,074 patients who received curative-intent radiation therapy treatment for HNC between 2010 and 2021 was reviewed. 47 patients who developed ORN as per the Notani classification were identified. Medical, dental and RT records of patients were reviewed retrospectively. Descriptive and statistical analysis was performed using SPSS. Results The incidence rate of ORN was 4.4%. The majority of patients were smokers (76.6%), drank alcohol (89.4%) and had no history of bisphosphonate therapy, with primary cancer of the oral cavity (68%). 36.4% of patients underwent pre-RT surgery involving bone. All patients were assessed by the dental hospital prior to treatment. Treatment intent was adjuvant (51%) or definitive (49%) and the mandible received ≥ 60Gy in 83% of patients.