ESTRO 2024 - Abstract Book

S1009

Clinical - Gynaecology

ESTRO 2024

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17. Heijkoop ST, Langerak TR, Quint S, Bondar L, Mens JWM, Heijmen BJM, et al. Clinical implementation of an online adaptive plan-of-the-day protocol for nonrigid motion management in locally advanced cervical cancer IMRT. Int J Radiat Oncol Biol Phys. 2014 Nov 1;90(3):673–9. 18. Buschmann M, Majercakova K, Sturdza A, Smet S, Najjari D, Daniel M, et al. Image guided adaptive external beam radiation therapy for cervix cancer: Evaluation of a clinically implemented plan-of-the-day technique. Z Med Phys. 2018 Aug 1;28(3):184–95.

890

Proffered Paper

Impact of cumulative cisplatin-dose on distant metastasis after chemoradiation of cervical cancer

Johannes Knoth 1 , Remi Nout 2 , Umesh Mahantshetty 3 , Ina Jürgenliemk-Schulz 4 , Christine Haie-Meder 5 , Lars U. Fokdal 6 , Alina Sturdza 1 , Peter Hoskin 7 , Barbara Segedin 8 , Kjersti Bruheim 9 , Fleur Huang 10 , Bhavana Rai 11 , Rachel Cooper 12 , Elzbieta van der Steen-Banasik 13 , Erik van Limbergen 14 , Bradley R. Pieters 15 , Li T. Tan 16 , Daniela Boryshchuk 17 , Astrid A.C. de Leeuw 4 , Nicole Nesvacil 1 , Kari Tanderup 6 , Christian Kirisits 1 , Jacob C. Lindegaard 6 , Richard Pötter 1 , Maximilian P. Schmid 1 1 Medical University/General Hospital of Vienna, Department of Radiation Oncology / Comprehensive Cancer Center, Vienna, Austria. 2 University Medical Center Rotterdam, Department of Radiotherapy, Erasmus MC Cancer Institute, Rotterdam, Netherlands. 3 Homi Bhabha Cancer Hospital & Research Centre, Visakhaptanam, Tata Memorial Centre, Mumbai, India. 4 University Medical Centre Utrecht, Department of Radiation Oncology, Utrecht, Netherlands. 5 Gustave-Roussy, Department of Radiotherapy, Villejuif, France. 6 Aarhus University Hospital, Department of Oncology, Aarhus, Denmark. 7 Mount Vernon Hospital, Mount Vernon Cancer Centre, Northwood, United Kingdom. 8 Institute of Oncology Ljubljana, Department of Radiotherapy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. 9 The Norwegian Radium Hospital - Oslo University Hospital, Department of Oncology, Oslo, Norway. 10 Cross Cancer Institute and University of Alberta, Department of Oncology, Edmonton, Canada. 11 Postgraduate Institute of Medical Education and Research, Department of Radiotherapy and Oncology, Chandigarh, India. 12 St James's University Hospital, Leeds Cancer Centre, Leeds, United Kingdom. 13 Radiotherapiegroep Arnhem, Department of Radiotherapy, Arnhem, Netherlands. 14 UZ Leuven, Department of Radiation Oncology, Leuven, Belgium. 15 Department of Radiation Oncology, Amsterdam University Medical Centers, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, Netherlands. 16 Department of Oncology, Addenbrooke´s Hospital, Cambridge University Hospitals, Cambridge, United Kingdom. 17 Medical University of Vienna, Center for Medical Data Science, Institute of Medical Statistics, Vienna, Austria

Purpose/Objective:

To assess the impact of cumulative cisplatin dose during definitive chemoradiation for cervical cancer on the risk of distant metastasis within the prospective observational multi-centre IntErnational study on MRI-guided BRAchytherapy in locally advanced CErvical Cancer (EMBRACE I) study.

Material/Methods: