ESTRO 2024 - Abstract Book

S1018

Clinical - Gynaecology

ESTRO 2024

recurrences. Estimated 4-year OS, DFS, LRFS, LRRFS, DMFS were 80.3%, 83.8%, 91.7%, 91.2%, and 92.4% respectively.

Conclusion:

Moderately hypofractionated whole pelvic radiotherapy followed by brachytherapy leads to descent long term clinical outcome albeit with slightly higher late GI toxicities. Relationship of D2cc dose to rectum with late toxicities derived from conventionally fractionated radiotherapy may not hold true for hypo-fractionated schedules and needs further research. The results of our study would serve as a prospective baseline data for the design of future clinical trials evaluating H-EBRT for LACC.

Keywords: Carcinoma Cervix, Hypo-fractionated, EBRT

References:

1. Gandhi AK, Rastogi M, Yadav U, Mishra V, Srivastava A, Bharati A, et al. A Pilot Study of Moderately Hypo Fractionated Whole Pelvic Radiotherapy with Concurrent Chemotherapy and Image-Guided High Dose Rate Brachytherapy for Locally Advanced Cervical Carcinoma. Int J Radiat Oncol Bio Phys 2022, 114 (3), Supplement S89. https://doi.org/10.1016/j.ijrobp.2022.07.500

1009

Mini-Oral

PARP-i combined with SBRT in oligoprogressive ovarian cancer: a multicentre retrospective experience

Stefano Durante 1 , Francesco Cuccia 2 , Roberta Lazzari 1 , Michele Rigo 3 , Giovanni Camminiti 4 , Federico Mastroleo 1,5 , Sabrina Vigorito 6 , Federica Cattani 7 , Giuseppe Ferrera 2 , Vito Chiantera 8,9 , Filippo Alongi 3,10 , Nicoletta Colombo 11,12 , Barbara Alicja Jereczek-Fossa 13,14 1 IEO European Institute of Oncology IRCCS, Radiation Oncology, Milan, Italy. 2 ARNAS Civico Hospital, Radiation Oncology Department, Palermo, Italy. 3 IRCCS Sacro Cuore Don Calabria Hospital, Advanced Radiation Oncology Department, Negrar di Valpolicella, Italy. 4 ASP 7, U.O.C. Radioterapia, Ragusa, Italy. 5 University of Piemonte Orientale (UPO), Department of Translational Medicine, Novara, Italy. 6 IEO European Institute of Oncology IRCCS, Unit of Medical Physics, Milan, Italy. 7 Unit of Medical Physics, Unit of Medical Physics, Milan, Italy. 8 National Cancer Institute - IRCCS - Fondazione 'G. Pascale', Unit of Gynecologic Oncology, Naples, Italy. 9 University of Palermo, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), Palermo, Italy. 10 University of Brescia, Division of Radiology and Radiotherapy, Brescia, Italy. 11 IEO European Institute of Oncology IRCCS, Gynecologic Oncology Program, Milan, Italy. 12 University of Milan-Bicocca, Department of Medicine and Surgery, Milan, Italy. 13 IEO European Institute of Oncology IRCCS, Division of Radiation Oncology, Milan, Italy. 14 University of Milan, Department of Oncology and Hemato-Oncology, Milan, Italy

Purpose/Objective: