ESTRO 2024 - Abstract Book

S1056

Clinical - Gynaecology

ESTRO 2024

found to be significant prognostic factors for LR and DM in multivariate analyses. These findings highlight the significance of these variables in multivariate regression analyses for predicting DM and LR. The 5- and 10-year OS rates were respectively 51.2% and 39.4%, with LRFS rates of 65.1% and 63.4% and DMFS rates of 72.4% and 69.6%. A Cox regression analysis revealed statistical significance in terms of Hgb, NLR, and PLR for 10-year LRFS. Higher Hgb levels (>9.82 g/dL) were associated with better outcomes, whereas lower NLR (2.92) and PLR (11.35) values were associated with better LRFS (p < 0.001, p < 0.001, and p = 0.005, respectively). Similarly, the analysis showed parallel results for 10-year DMFS (p < 0.001, p < 0.001, and p < 0.001, respectively). Tumor size, lymph node metastasis, and NLR were identified by multivariate analyses as significant prognostic factors of LRFS. Both univariate and multivariate analyses of DMFS demonstrated the predictive value of Hgb, NLR, and lymph node metastasis.

Conclusion:

With a median follow-up of more than ten years, our study found that hematological parameters such as NLR and Hgb levels have the potential to serve as indicators of disease recurrence in cervical cancer patients who have received definitive chemoradiotherapy. Our results underscore the importance of closely monitoring recurrences, especially during the initial two years of follow-up, as they predominantly occurred within this timeframe.

Keywords: cervical cancer, radiotherapy, NLR, PLR, Hg

2034

Mini-Oral

Morbidity profile of different lymph node management strategies in node positive cervical cancer

Alexandru-Teodor Zaharie, Johannes Knoth, Alina E Sturdza, Richard Pötter, Joachim Widder, Maximilian P Schmid

Medical University of Vienna, Radiation Oncology, Vienna, Austria

Purpose/Objective:

In a previous analysis we investigated the impact of different lymph node (LN) management strategies on regional lymph node control (RNC) in patients with LN positive locally advanced cervical cancer (LACC) undergoing definitive chemoradiation (CRT) and image guided adaptive brachytherapy (IGABT) showing that omission of either surgical LN resection and/or LN boost leads to poor RNC. The aim of the current study is to analyze treatment related morbidity in the same cohort.

Material/Methods:

All patients with pelvic and/or paraaortic nodal disease at diagnosis (FIGO stage IIIC1-2) treated at our institution within the retrospective retroEMBRACE study and the prospective EMBRACE I and II studies with morbidity data available were considered for analysis. Patients were grouped based on the respective LN management: (1) surgical staging (OP) with complete resection of all macroscopic LN disease by sampling, debulking, or complete lymphadenectomy followed by 45-50.4Gy CRT (surgery + CRT group); (2) 45-50.4Gy CRT + LN boost up to 60 Gy EQD2 without surgical staging (CRT + boost group); (3) 45-50.4Gy CRT with neither LN boost nor surgical staging