ESTRO 2024 - Abstract Book

S1097

Clinical - Gynaecology

ESTRO 2024

Keywords: MR-Linac, tomotherapy, adaptive

References:

1. Gandhi A.K., Sharma D.N., Rath G.K. et al. Early Clinical Outcomes and Toxicity of Intensity Modulated versus Conventional Pelvic Radiation Therapy for Locally Advanced Cervix Carcinoma: a Prospective Randomized Study. Int J Radiat Oncol Biol Phys (2013) Vol 87(3): 542-8.

2. Lin Y., Chen K.C., Zhao L.L. et al. Intensity-modulated Radiation Therapy for Definitive Treatment of Cervical Cancer: a Meta-analysis. Radiat Oncol (2018) Vol 13(1): 177.

3. Yu C., Zhu Y.J., Gui P.P. et al. A Comparative Study of Intensity-Modulated Radiotherapy and Standard Radiation Field with Concurrent Chemotherapy for Local Advanced Cervical Cancer. Eur J Gynaecol Oncol (2015) Vol 36 (3): 278-72.

4. Winkel D., Bol G.H., Kroon P.S. et al. Adaptive Radiotherapy: The Elekta Unity MR-Linac Concept. Clin Transl Radiat Oncol (2019) Vol 18: 54-59.

5. Ingle M. and Lalondrelle S. Current Status of Anatomical Magnetic Resonance Imaging in Brachytherapy and External Beam Radiotherapy Planning and Delivery. Clin Oncol (R Coll Radiol) (2020) Vol 32(12): 817-827.

6. Portelance L., Corradini S., Erickson B. et al. Online Magnetic Resonance-Guided Radiotherapy (oMRgRT) for Gynecological Cancers. Front Oncol (20121) Vol 11: 628131.

2645

Digital Poster

Early regression index (ERI) for the prediction of local control in locally advanced cervical cancer

ROSA AUTORINO 1 , LUCA RUSSO 2 , DAVIDE CUSUMANO 3 , LUCA BOLDRINI 1 , VALENTINA LANCELLOTTA 1 , EVIS SALA 4 , BENEDETTA GUI 4 , MARIA ANTONIETTA GAMBACORTA 1 1 4. UOC Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Radiotherapy, Rome, Italy. 2 4. UOC Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Radiodiagnostic, Rome, Italy. 3 4. UOC Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Physics, Rome, Italy. 4 4. UOC Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Radiology, Rome, Italy

Purpose/Objective:

Early Regression Index (ERI) is an image-based biomarker which combines gross tumour volume (GTV) measured at staging (Vpre) and at mid-therapy (Vmid) to quantify early tumour shrinkage. It showed promising results in predicting pathological complete response (pCR) in rectal and cervical cancer treated with neoadjuvant chemoradiotherapy.