ESTRO 2024 - Abstract Book

S1139

Clinical - Haematology

ESTRO 2024

75.0%, comparable to the 89.7% CR rate observed in the 30.6 Gy group. Bilaterality emerged as a significant risk factor for local recurrence in univariate analysis, while the radiation dose did not exhibit a significant correlation.

Further analysis revealed that 14 cases (31.1%) were bilateral, and 31 (68.9%) were ipsilateral. Clinical response assessment indicated that 93.5% of ipsilateral cases achieved CR, whereas 64.3% in bilateral cases showed CR. While bilaterality remained a significant risk factor in univariate analysis, the lower radiation dose did not. During the follow-up period, local recurrence was experienced by 2 cases (4.5%). Univariate analysis for local recurrence identified bilaterality as a significant risk factor (p=0.032), but radiation dose did not exhibit statistical significance. Toxicity analysis focused on cataract occurrence relative to radiation dose. Among the total cases, cataract developed in 13 (28.9%) patients. Comparison based on radiation dose revealed that 18.8% of cases treated with 20 Gy and 34.5% of cases treated with 30.6 Gy experienced cataract. However, univariate analysis did not establish a statistical correlation between cataract occurrence and radiation dose. Overall, the cumulative incidence of cataract at 3 years was 17% in the 20 Gy group and 31% at 5 years, while in the 30.6 Gy group, it was 17% at 3 years and 26% at 5 years. These results suggest that the 20 Gy group is comparable to the 30.6 Gy group in terms of local control and cataract occurrence over the specified follow-up period.

Conclusion:

In conclusion, both radiation doses demonstrated comparable efficacy in achieving local control. The study emphasizes the importance of considering bilaterality and clinical response as significant factors influencing local recurrence, while radiation dose did not emerge as a primary determinant. Cataract occurrence did not exhibit a correlation with radiation dose, advocating the safety of both regimens. Long-term follow-up remains imperative for a comprehensive understanding of treatment outcomes.

Keywords: Conjunctival MALT lymphoma, Reduced Dose,