ESTRO 2024 - Abstract Book

S1150

Clinical - Haematology

ESTRO 2024

1270

Proffered Paper

Modern radiotherapy for extended cutaneous lesions from lymphomas: results from a multi-center study

Mario Levis 1 , Fabio Matrone 2 , Gabriele Simontacchi 3 , Michela Buglione 4 , Michael Oertel 5 , Patrizia Ciammella 6 , Pierina Navarria 7 , Marco Galaverni 8 , Emanuela Olmetto 3 , Sara Bartoncini 1 , Khaled Elsayad 5 , Andrea Guerini 4 , Monica Mangoni 9 , Chiara Cavallin 1 , Stephan Rehn 5 , Emanuele Alì 6 , Damiano Dei 7 , Paola De Franco 10 , Giuliana Pascale 11 , Ilenia Iamundo De Cumis 12 , Alessandra Donofrio 2 , Claudia Grondelli 8 , Francesca Clot 1 , Hans T Eich 5 , Umberto Ricardi 1 1 University of Torino, Department of Oncology, Torino, Italy. 2 Centro di Riferimento Oncologico CRO Aviano, Department of Radiation Oncology, Aviano, Italy. 3 AOU Careggi, Radiotherapy unit, Firenze, Italy. 4 University of Brescia, Department of Oncology, Brescia, Italy. 5 University Hospital Muenster, Department of Radiation Oncology, Muenster, Germany. 6 AUSL IRCCS di Reggio Emilia, Radiation Oncology Unit, Reggio Emilia, Italy. 7 Humanitas Research Hospital, Radiotherapy and Radiosurgery Department, Rozzano, Milano, Italy. 8 AOU di Parma, Radiotherapy unit, Parma, Italy. 9 University of Firenze, Department of Experimental and clinical biomedical sciences "Mario Serio", Firenze, Italy. 10 Ospedale Vito Fazzi, U.O. Radioterapia Oncologica, Lecce, Italy. 11 IRCCS Dino Amadori, Radiotherapy Unit, Meldola, Italy. 12 Businco Hospital, ARNAS G. Brotzu, Department of Radiation Oncology, Cagliari, Italy Cutaneous lymphomas are a heterogeneous group of highly radiosensitive diseases and radiotherapy (RT) is a highly effective skin directed therapy in case of either primary or secondary skin involvement. Given the superficial localization of these lesions, electron beam therapy is largely adopted and delivered locally (EBT) or comprehensively to the total skin (TSEBT), depending on clinical indication (1) . However, the treatment of extended or irregularly shaped cutaneous lesions is often unfeasible with EBT for technical reasons or not indicated with TSEBT for clinical reasons. Modern and highly conformal delivery techniques, such as intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT), may be a possible solution to solve this unmeet clinical need. Literature data on the adoption of modern techniques in this setting are scarse and limited to case reports (2-3) . In this multi-institutional collaboration, we report real-world data in the largest published series to date with the aim of demonstrating the safety and the efficacy of IMRT and VMAT to treat extended primary or secondary cutaneous lesions in lymphoma patients. Purpose/Objective:

Material/Methods:

We conducted a multi-institutional retrospective analysis, including data from 10 Italian and 1 German institutions. The study was approved by the ethical committee of each participating center. Eligibility criteria included a histological confirmation of lymphoproliferative disorder, receipt of a RT course planned with a high dose-gradient technique (IMRT or VMAT) and delivered with a conventional LINAC or with helical tomotherapy (HT) between 2010 and 2023 and age >=18 at the time of treatment. Primary endpoints were overall response rate (ORR) and acute treatment-related morbidity, defined as the appearance of any skin adverse event (AE). ORR was defined as the achievement of complete response (CR) or partial response (PR) and was estimated at least 1 month after the end