ESTRO 2024 - Abstract Book

S1178

Clinical - Head & neck

ESTRO 2024

18

Digital Poster

Secondary analysis of JCOG1008: Frequency and risk factors associated with the hypothyroidism

Hidetoshi Shimizu 1 , Takeshi Kodaira 1 , Naomi Kiyota 2 , Ryuichi Hayashi 3 , Hiroshi Nishino 4 , Yukinori Asada 5 , Hiroki Mitani 6 , Yuuji Hirayama 7 , Yusuke Onozawa 8 , Naoki Nishio 9 , Nobuhiro Hanai 10 , Akira Ohkoshi 11 , Hiroki Hara 12 , Nobuya Monden 13 , Masato Nagaoka 14 , Shujiro Minami 15 , Takashi Fujii 16 , Kaoru Tanaka 17 , Akihiro Homma 18 , Keita Sasaki 19 , Ryo Kitabayashi 19 , Satoshi Ishikura 20 , Yasumasa Nishimura 21 , Makoto Tahara 22 1 Aichi Cancer Center Hospital, Department of Radiation Oncology, Nagoya, Japan. 2 Kobe University Hospital, Department of Medical Oncology and Hematology, Kobe, Japan. 3 National Cancer Center Hospital East, Department of Head and Neck Surgery, Kashiwa, Japan. 4 Jichi Medical University Hospital, Department of Otolaryngology-Head and Neck Surgery, Shimotsuke, Japan. 5 Miyagi Cancer Center, Department of Head and Neck Surgery, Natori, Japan. 6 Cancer Institute Hospital, Department of Head and Neck Oncology, Tokyo, Japan. 7 Hyogo Cancer Center, Department of Head and Neck Surgery, Akashi, Japan. 8 Shizuoka Cancer Center, Division of Clinical Oncology, Shizuoka, Japan. 9 Nagoya University Hospital,, Department of Otorhinolaryngology, Nagoya, Japan. 10 Aichi Cancer Center Hospital, Department of Head and Neck Surgery, Nagoya, Japan. 11 Tohoku University Hospital, Department of Otolaryngology-Head and Neck Surgery, Sendai, Japan. 12 Saitama Cancer Center,, Department of Gastroenterology, Ina, Japan. 13 National Hospital Organization Shikoku Cancer Center, Department of Head and Neck Surgery, Matsuyama, Japan. 14 Jikei University School of Medicine, Department of Otolaryngology, Tokyo, Japan. 15 National Hospital Organization Tokyo Medical Center, Department of Otolaryngology, Tokyo, Japan. 16 Osaka International Cancer Institute, Department of Head and Neck Surgery, Osaka, Japan. 17 Kindai University Hospital, Department of Medical Oncology, Osakasayama, Japan. 18 Faculty of Medicine and Graduate School of Medicine, Department of Otolaryngology - Head & Neck Surgery, Sapporo, Japan. 19 National Cancer Center Hospital, Japan Clinical Oncology Group Data Center/Operations office, Tokyo, Japan. 20 Tokyo Bay Makuhari Clinic for Advanced Imaging, Cancer Screening, and High-Precision Radiotherapy, Division of Radiation Oncology, Chiba, Japan. 21 Kindai University, Professor emeritus, Osakasayama, Japan. 22 National Cancer Center Hospital East, Department of Head and Neck Medical Oncology, Chiba, Japan

Purpose/Objective:

Hypothyroidism is a well-known late adverse event after radiotherapy for head and neck cancer, and it requires long-term medical intervention and increases the patient burden. A multi-institutional open-label phase II/III trial of JCOG1008 proved the non-inferiority of weekly cisplatin to 3-weekly cisplatin for postoperative radiotherapy in high risk patients with squamous cell carcinoma of the head and neck. The aim of this analysis was to elucidate the factors associated with hypothyroidism by analyzing the association between hypothyroidism and clinical or dosimetric characteristics, using JCOG1008 data.

Material/Methods: