ESTRO 2024 - Abstract Book

S1197

Clinical - Head & neck

ESTRO 2024

Further research is required to validate this association and to propose methods to stimulate treatment completion.

Keywords: Overall treatment time, comorbidity

References:

1 - McAleese, J., Mooney, L., & Walls, G. . (2021). Reducing the Risk of Death From Pneumocystis jirovecii Pneumonia After Radical Radiation Therapy to the Lung [Article]. Clinical Oncology (Royal College of Radiologists (Great Britain)), 33(12), 780 – 787. https://doi.org/10.1016/j.clon.2021.06.010

2 - Sarfati, D., Koczwara, B., & Jackson, C. (2016). The impact of comorbidity on cancer and its treatment. CA: A Cancer Journal for Clinicians, 66(4), 337 – 350. https://doi.org/10.3322/caac.21342

3

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RCP.

(n.d.).

Adult

co-morbidity

evaluation

(ACE-27)

|

RCP

London.

2 – 3.

https://www.rcplondon.ac.uk/file/3058/download

474

Digital Poster

Unknown primary head & neck SCC: Involved neck only radiotherapy and incidental dose to oropharynx

Wai-Yan Poon 1 , Adam Peters 1 , Laura Grocutt 2 , Ronan Valentine 2 , Caroline Lowrie 1 , Christina Wilson 1 , Derek Grose 1 , Carolynn Lamb 1 , Saurabh Vohra 1 , Stefano Schipani 1 , Claire Paterson 1 1 Beatson West of Scotland Cancer Centre, Clinical Oncology, GLASGOW, United Kingdom. 2 Beatson West of Scotland Cancer Centre, Physics, GLASGOW, United Kingdom

Purpose/Objective:

Squamous cell carcinoma of unknown primary (SCCUP) in the head and neck is rare and accounts for less than 5% of all head and neck cancers. 1 The optimal management of SCCUP remains poorly defined and may include surgery or (chemo) radiotherapy (RT). Target volumes for RT are inconsistent. There remains much controversy regarding involved neck only (INO) versus bilateral neck and mucosal (MUC) RT treatment and the volume of mucosa harbouring potential primary sites that may be covered prophylactically with RT. 2 There has been increasing traction for INO RT with evidence suggesting this may be a safe approach. 3 A recent, national multicentre series demonstrated poorer outcomes with surgery (neck dissection) alone compared to treatment that included RT. 4 The disparity in outcomes between surgery to neck alone Vs RT to neck alone (INO) has not been previously investigated. Our hypothesis is that that the oropharynx receives a therapeutic incidental dose of RT even with INO RT.

The aim of this work is to review long term clinical outcomes in patients with SCCUP treated with INO RT, and to evaluate the incidental dose to potential primary sites using this approach.