ESTRO 2024 - Abstract Book

S1208

Clinical - Head & neck

ESTRO 2024

592

Digital Poster

Impact of hippocampal-, cochlea-, and scalp-sparing in WBRT: a systematic review endorsed by AIRO

Donato Pezzulla 1 , Francesca Maurizi 2 , Luigi De Cicco 3 , Valentina Borzillo 4 , Francesco Beghella Bartoli 5 , Anna Viola 6 , Fabiana Gregucci 7 , Elena Clerici 8 , Isacco Desideri 9 , Andrea Guerini 10 , Barbara Diletto 11 , Claudia Scarigni 12 , Camilla Delli Paoli 13 , Elisabetta Bonzano 14 , Silvia Longo 5 , Alice Zamagni 15 , Angela Argenone 16 , Alberto Cacciola 17 , Silvia Colombo 18 , Esmeralda Scipilliti 4 , Giovanni Carlo Mazzola 19 , Luca Bergamaschi 19 , Silvia Chiesa 5 , Valentina Pinzi 20 , Rossella Di Franco 4 1 Responsible Research Hospital, Radiation Oncology Unit, Campobasso, Italy. 2 A.O. Ospedali Riuniti Marche No, Radiation Oncology, Pesaro, Italy. 3 ASST of Olona Valley, Division Of radiation Oncology, Busto Arsizio, Italy. 4 Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, department of Radiation oncology, Napoli, Italy. 5 Fondazione Policlinico Universitario Gemelli IRCCS, UOC di Radioterapia Oncologica, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Roma, Italy. 6 University of Messina, IBD-Unit, Department of Clinical and Experimental Medicine, Messina, Italy. 7 F. Miulli General Regional Hospital, Acquaviva delle Fonti, department of Radiation oncology, Bari, Italy. 8 Humanitas Clinical and Research Center – IRCCS, department of Radiation oncology, Rozzano, Italy. 9 Azienda Ospedaliero-Universitaria Careggi, Radiation Oncology, Firenze, Italy. 10 ASST Spedali Civili of Brescia, University of Brescia, Radiation Oncology Unit, Department of Medical and Surgical Specialties, Radiological Science and Public Health, Brescia, Italy. 11 Fondazione IRCCS Istituto Nazionale Tumori, Pediatric Radiotherapy Unit, Milano, Italy. 12 San Giovanni-Addolorata Hospital, department of Radiation oncology, Roma, Italy. 13 Firenze-Azienda Sanitaria USL Toscana Centro, S.C: Radioterapia, Firenze, Italy. 14 Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Matteo Polyclinic Foundation, department of Radiation oncology, Pavia, Italy. 15 Alma Mater Studiorum Bologna University, Radiation Oncology, Department of Experimental Diagnostic and Specialty Medicine (DIMES), Bologna, Italy. 16 Azienda Ospedaliera di Rilievo Nazionale San Pio, Division Of radiation Oncology, Benevento, Italy. 17 A.O.U. "G. Martino", Radiation Oncology Unit, Messina, Italy. 18 Fondazione IRCCS Policlinico San Matteo, Division of Radiation Oncology, Department of Hemato-Oncology, Pavia, Italy. 19 IEO European Institute of Oncology IRCCS, Division Of Radiation Oncology, Milano, Italy. 20 Fondazione IRCCS Istituto Neurologico Carlo Besta, Neurosurgery Department, Radiotherapy Unit, Milano, Italy

Purpose/Objective:

We search the current literature on data regarding the role of Whole-Brain Radiation Therapy (WBRT) on neurocognitive functions, hearing and alopecia, through the use of hippocampal-, cochlea-, and scalp-sparing respectively.

Material/Methods:

This systematic review followed the PRISMA recommendations. Prospective and retrospective studies with at least 5 patients were included in this analysis. The papers performing a cognitive or a scalp evaluation in patients treated with WBRT with Hippocampal Sparing using a control group were included in the meta-analysis.