ESTRO 2024 - Abstract Book

S1217

Clinical - Head & neck

ESTRO 2024

LVI (yes. vs. no)

1.34 (0.81-2.21)

0.26

PNI (yes. vs. no)

1.24 (0.82-1.86)

0.31

Extranodal extension (yes. vs. no)

2.55 (1.50-4.33)

0.001

Adjuvant treatment (CRT vs. RT)

0.83 (0.53-1.31)

0.43

Pre-treatment SMI

0.97 (0.94-0.99)

0.02

SMI loss ≥4.2%

9.15 (6.05-13.82)

<0.001

Conclusion:

Muscle loss ≥4.2% during radiotherapy may be a cut-off associated with survival outcomes in oral cavity cancer. Using XAI, clinically useful cut-off of muscle loss may be identified and subsequently externally validated.

Keywords: Oral cavity cancer, Muscle loss, Explainable AI

References:

1. Lee J, Liu SH, Chen JC, Leu YS, Liu CJ, Chen YJ. Progressive muscle loss is an independent predictor for survival in locally advanced oral cavity cancer: A longitudinal study. Radiother Oncol. 2021;158:83-9.

2. Ladbury C, Li R, Danesharasteh A, Ertem Z, Tam A, Liu J et al. Explainable Artificial Intelligence to Identify Dosimetric Predictors of Toxicity in Patients with Locally Advanced Non-Small Cell Lung Cancer: A Secondary Analysis of RTOG 0617. Int J Radiat Oncol Biol Phys. 2023. doi: 10.1016/j.ijrobp.2023.06.019.

3. Li R, Shinde A, Liu A, Glaser S, Lyou Y, Yuh B et al. Machine Learning-Based Interpretation and Visualization of Nonlinear Interactions in Prostate Cancer Survival. JCO Clin Cancer Inform. 2020;4:637-46.

689

Mini-Oral

Diffusion-weighted MRI to predict treatment outcome and HPV status in oropharyngeal carcinoma

Heleen Bollen 1 , Rüveyda Dok 2 , Sarah Deschuymer 3 , Annouschka Laenen 4 , Frederik De Keyzer 5 , Vincent Vandecaveye 5 , Robert Hermans 5 , Sandra Nuyts 1 1 University Hospitals Leuven, Laboratory of Experimental Radiotherapy, Leuven, Belgium. 2 Catholic University Leuven, Laboratory of Experimental Radiotherapy, Leuven, Belgium. 3 University Hospitals Ghent, Radiotherapy Oncology, Ghent, Belgium. 4 Catholic University Leuven, Biostatistics and Statistical Bioinformatics Center, Leuven, Belgium. 5 University Hospitals Leuven, Radiology, Leuven, Belgium

Purpose/Objective: