ESTRO 2024 - Abstract Book

S1245

Clinical - Head & neck

ESTRO 2024

composition of the patients selected. This study demonstrates that a mildly accelerated Quad Shot regimen is not only effective and well-tolerated but also a practical and viable option for HNC patients ineligible for curative treatments.

Keywords: accelerated quad shot, palliation, community

References:

1. Spanos W Jr, Guse C, Perez C, Grigsby P, Doggett RL, Poulter C. Phase II study of multiple daily fractionations in the palliation of advanced pelvic malignancies: preliminary report of RTOG 8502. Int J Radiat Oncol Biol Phys. 1989;17(3):659 – 61. 2. Corry J, Peters LJ, Costa ID, Milner AD, Fawns H, Rischin D, Porceddu S. The 'QUAD SHOT'--a phase II study of palliative radiotherapy for incurable head and neck cancer. Radiother Oncol. 2005 Nov;77(2):137-42. doi: 10.1016/j.radonc.2005.10.008. Epub 2005 Nov 2. PMID: 16260054.

1093

Mini-Oral

Feeding Tube Strategy during Radical Radiotherapy in Head & Neck Cancer: Phase III Randomised Trial

Sarbani Ghosh Laskar 1 , Shwetabh Sinha 2 , Meenakshi J 1 , Anuj Kumar 2 , Samarpita Mohanty 2 , Purabi Mahajan 3 , Arun Balaji 4 , Rukmangathan TM 4 , Faizalam Khan 1 , Ashwini Budrukkar 1 , Monali Swain 1 1 Tata Memorial Hospital, Radiation Oncology, Mumbai, India. 2 Advanced Centre for Training, Research and Education in Cancer, Radiation Oncology, Mumbai, India. 3 Tata Memorial Hospital, Nutrition, Mumbai, India. 4 Tata Memorial Hospital, Speech and Swallowing Therapy, Mumbai, India

Purpose/Objective:

The optimal feeding tube strategy (Prophylactic vs Reactive insertion) during Radiation Therapy (RT) for Head and Neck Squamous Cell Carcinoma (HNSCC) remains unestablished. The primary endpoint of this study was to compare the proportion of patients with significant weight loss (defined as >10% of baseline weight loss) at six months post-RT between prophylactic and reactive tube feeding.

Material/Methods:

This randomized, phase III, superiority trial included patients of HNSCC (oral cavity, oropharynx, larynx, and hypopharynx) planned for curative RT. Patients were randomized (1:1) to prophylactic [patients undergoing a nasogastric tube (NGT) or Percutaneous Endoscopic Gastrostomy (PEG) before starting RT] or reactive (patients undergoing NGT or PEG insertion as deemed required by the radiation oncologist) feeding tube insertion. Patients