ESTRO 2024 - Abstract Book

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S1264

Clinical - Head & neck

ESTRO 2024

1213

Digital Poster

Comparison of disease outcomes between younger and older patients with carcinoma oral tongue

Shaifali Mahajan, Parveen Ahlawat, Sandeep Purohit, Akash Bellige, Gerim Prasai, Munish Gairola, Sarthak Tandon

Rajiv Gandhi Cancer Institute and Research Centre, Radiation Oncology, New Delhi, India

Purpose/Objective:

To compare the clinicopathological profile and disease related outcomes (loco-regional control (LRC) and overall survival (OS)) between younger (40 years or lesser) and older cohorts (ages of over 40 years) with resectable oral tongue squamous cell cancer (OTSCC) patients who underwent combined modality treatment (surgery followed by adjuvant radiotherapy ± concurrent chemotherapy).

Material/Methods:

A retrospective comparative study at a tertiary oncology centre in India comprising 650 primary OTSCC patients over a duration of 2008 to 2022. This study included patients with local/ locoregional disease who underwent combined modality treatment with upfront surgical resection. Adjuvant radiotherapy ± concurrent chemotherapy were administered as per the risk factors present in final surgical histopathological report. The endpoints of 3-year and 5-year LRC and OS were calculated using Kaplan-Meier product-limit method. Univariate and multivariate Cox proportional hazards regression analysis was performed. Statistical analyses were done using SPSS version 20 and p-value <0.05 was considered statistically significant.

Results:

Of the total 650 patients, 461 (70.9%) were in the older cohort and 189 (29.1%) in the younger cohort at diagnosis. General patient characteristics were balanced in the two cohorts. Factors found to be statistically significantly different between the two groups were gender, co-morbidities, smoking, smokeless tobacco, and alcohol consumption. Median follow-up for the younger and older cohort was 22.9 months and 23.7 months respectively. Based on univariate and multivariate analysis, tumour grade, tumour margins, perineural invasion (PNI), pNodal stage, and extracapsular extension (ECE) were statistically significant for LRC. Tobacco smoking, tumour grade, tumour margins, PNI, pN stage, and ECE were statistically significant for OS. (Table 1)

Table1: Univariate and multivariate analysis for prognostic factors affecting (OS)

Univariate Analysis

Multivariate Analysis

Variable