ESTRO 2024 - Abstract Book

S1282

Clinical - Head & neck

ESTRO 2024

Figure 1. Kaplan-Meier curves for the overall survival model and progression-free survival mode.

Conclusion:

In this study, comprehensive prediction models for treatment outcomes in NPC patients were developed and validated. The models for OS and PFS performed better than models based on the AJCC-stage only, therefore more optimal treatment decisions can be made for individual patients.

Keywords: Nasopharyngeal carcinoma,Treatment outcome,Models

1306

Digital Poster

A Systematic Review on RT CTV Delineation for Nasopharyngeal Carcinoma after Induction Chemotherapy

Omar Nouri 1 , Ryan Anthony Agas 2 , Lester Brayn Co 2 , Audrey LARNAUDIE 3 , Hela Hammami Turki 4 , Clevelind Calma 5,6 , Melvin Lee Kiang Chua 7,8 , Chong Zhao 9 , Jamel Daoud 1 , Michael Benedict Mejia 2 , Warren Bacorro 2,5 , Nejla Fourati 1 1 Habib Bourguiba Hospital, Radiation Oncology, Sfax, Tunisia. 2 Benavides Cancer Institute, Radiation Oncology, Manila, Philippines. 3 Centre François Baclesse, Radiation Oncology, Caen, France. 4 Centre Médical Les Jasmins, Radiation Oncology, Tunis, Tunisia. 5 Faculty of Medicine and Surgery, Clinical epidemiology, Manila, Philippines. 6 Benavides Cancer Institute, Section of medical oncology, Manila, Philippines. 7 National Cancer Centre Singapore, Head and Neck and Thoracic Cancers, Singapore, Singapore. 8 Duke-NUS Medical School, Oncology Academic Programme, Singapore, Singapore. 9 Sun Yat-sen University Cancer Centre, Radiation Oncology, Guangzhou, China

Purpose/Objective:

Induction chemotherapy (IC) has recently become a therapeutic standard for locally advanced nasopharyngeal carcinoma (NPC) [1,2]. Post-IC radiotherapy (RT) clinical target volume (CTV) delineation protocols and dose level prescriptions vary importantly in published studies. We conducted a systematic review to inform a planned consensus guidelines development.

Material/Methods:

Between August and October 2023, a scoping review of guidelines and reviews was done to define areas of significant practice differences, followed by a systematic review of experimental and observational studies to synthesize published evidence. The reviews were guided by a steering committee (SC) and conducted by an evidence review committee (ERC), consisting of radiation oncologists from endemic regions with expertise in NPC treatment. Systematic searches were done on PubMed and ScienceDirect including papers from the last ten years and employing both controlled vocabulary and free-text search terms.