ESTRO 2024 - Abstract Book

S1284

Clinical - Head & neck

ESTRO 2024

5. XIANG, Li, RONG, Jin-Feng, LI, Xiao-Yue, et al. Reducing Target Volumes of Intensity Modulated Radiation Therapy After Induction Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma: Long-Term Results of a Prospective, Multicenter, Randomized Trial. International Journal of Radiation Oncology* Biology* Physics, 2023. 6. BACORRO, FOURATI, TURKI, AGAS, NOURI, CO, et al. A Protocol for International Consensus Guideline Development on the Delineation of Radiotherapy Target Volumes for Nasopharyngeal Carcinoma after Induction Chemotherapy. Annals of Nasopharynx Cancer. Under review.

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Detection of Early Relapse by FDG-PET in the NPC Patients with Post-RT Detectable Plasma EBV DNA

CHING-TE WU 1 , Wen-Yi Wang 2 , Chih-Wen Twu 3 , Jin-Ching Lin 4

1 Changhua Show Chwan Memorial Hospital, Department of Radiation Oncology, Changhua, Taiwan. 2 Hung Kuang University, Department of Nursing, Taichung, Taiwan. 3 Changhua Christian Hospital, Department of Otorhinolaryngology, Changhua, Taiwan. 4 Changhua Christian Hospital, Department of Radiation Oncology, Changhua, Taiwan

Purpose/Objective:

Nasopharyngeal carcinoma (NPC) patients with persistently detectable plasma EBV DNA after

combined radiotherapy (RT) and chemotherapy have a high relapse rate and short survivals. The

aim of this study is to investigate the role of 18 F-FDG PET/CT scan within 3 months after finishing

RT in these high-risk subgroup patients.

Material/Methods:

We screened 632 newly diagnosed NPC patients without distant metastasis during December 2008

to October 2018 and found 90 patients (14.2%) with persistently detectable plasma EBV DNA one

week after finishing RT. Thirty-seven patients were excluded due to no post-RT PET/CT scan

examination or PET/CT scan performed more than 3 months after RT. The baseline characteristics

of 53 eligible patients were median age 49 (range 20-81) years old, male/female=35/18, stage

II/III/IV=3/15/35. We analyzed the detection yield of tumor relapse by PET/CT scan within 3