ESTRO 2024 - Abstract Book

S1337

Clinical - Head & neck

ESTRO 2024

Figure 2: Kaplan Meier curve showing LFS. Censor points are defined as date last seen alive or death from any cause.

Conclusion:

Hypofractionated RT demonstrates favourable five-year outcomes for organ preservation and DSS in early larynx cancer. However, organ preservation and DSS were less favourable in the 55/20 group, likely due to the higher T stage. Our real-world findings are comparable with other published trials on hypofractionated regimens in early larynx cancer, which demonstrated DSS rates ranging from 90% to 100% and LFS rates between 79.1% and 90% 1-3,8 11 . These findings underscore the efficacy of hypofractionated RT as a treatment option for early larynx cancer, offering patients a shorter, more convenient, and possibly more effective course of treatment compared to conventional RT.

Keywords: Hypofractionation, Radiotherapy, Larynx Cancer

References:

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[2] Shor S, Krawitz H, Macann A, West T, Morton RP, Mcivor NP, et al. T1N0/T2N0 glottic carcinoma: A comparison of two fractionation schedules. Australas Radiol. 2006;50(2):152-157. doi:10.1111/j.1440-1673.2006.01559.x

[3] Kim TG, Ahn YC, Nam HR, Chung MK, Jeong HS, Son YI, et al. Definitive radiation therapy for early glottic cancer: Experience of two fractionation schedules. Clin Exp Otorhinolaryngol. 2012;5(2):94-100. doi:10.3342/ceo.2012.5.2.94