ESTRO 2024 - Abstract Book

S1344

Clinical - Head & neck

ESTRO 2024

2. Protection of other organs at risk

By sparing the tongue, high dose was shifted into the mandible bone. Thus, there would occur a higher dose (p = 0,0215). The average dose of the mandible was 43,0 Gy (Treatment) vs. 50,97 Gy (Simulation). All other common constraints for the radiation of head and neck tumors, especially the ones for the parotids were still fulfilled (D mean right parotid: 19,76 Gy (Treatment) vs. 19,06 Gy (Simulation) and D mean left parotid: 22,06 Gy (Treatment) vs. 19,51 Gy (Simulation).

3. Coverage of PTV

There was a homogenous coverage of the target volume, which did not differ statistically. This applied to all dose levels (PTV > 60 Gy, PTV 60 Gy and PTV 54 Gy).

Conclusion:

Sparing and protection of the tongue is possible without any significant additional dose load to other organs at risk, apart from the mandible as described. Thereby, a good coverage of the PTV in all dose levels was achieved. Thus, it is now possible to prospectively correlate the sparing of the tongue with subjectively experienced changes in taste and smell. It is our aim to develop dose constraints for the different parts of the tongue which lead to a reduction of dysgeusia when regularly used. This should result in a higher quality of life, fewer restrictions on food intake and better adherence to therapy.

Keywords: acute toxicity, organs at risk, dose sparing

References:

1. Leitzen C, Herberhold S, Wilhelm-Buchstab T, Garbe S, Müdder T, Schoroth F, Schild HH, Bootz F, Schüller H. Change of Taste during and after IM- /IG-Radiotherapy for Head and Neck Cancer Patients. Laryngorhinootologie. 2015 Jun;94(6):383-7. German. doi: 10.1055/s-0034-1390430. Epub 2014 Dec 1. PMID: 25437837.

2. Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA, Heaivilin N, Zumsteg ZS. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory