ESTRO 2024 - Abstract Book

S1389

Clinical - Head & neck

ESTRO 2024

In surgical patients TLG and shamMARD showed a significant association with PFS (p < 0.001 uni- and multivariate), but in contrast to primary irradiated patients, the stratification of TLG could not be improved by shamMARD.

Conclusion:

Integration of metabolic information for calculation of personalized radiation doses is feasible and seems to be a promising approach in HNSCC. Ongoing research will investigate further imaging parameters in a larger cohort of patients and the potential of a combined genome and metabolic adapted radiation dose for the future use in precision radiation oncology.

Keywords: personalized radiotherapy, metabolic adapted dose

References:

[1] Scott JG, Berglund A, Schell MJ, Mihaylov I, Fulp WJ, Yue B, Welsh E, Caudell JJ, Ahmed K, Strom TS, Mellon E, Venkat P, Johnstone P, Foekens J, Lee J, Moros E, Dalton WS, Eschrich SA, McLeod H, Harrison LB, Torres-Roca JF. A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study. Lancet Oncol. 2017 Feb;18(2):202-211. doi: 10.1016/S1470-2045(16)30648-9. Epub 2016 Dec 18. Erratum in: Lancet Oncol. 2017 Feb;18(2):e65. [2] Zschaeck S, Weingärtner J, Lombardo E, Marschner S, Hajiyianni M, Beck M, Zips D, Li Y, Lin Q, Amthauer H, Troost EGC, van den Hoff J, Budach V, Kotzerke J, Ferentinos K, Karagiannis E, Kaul D, Gregoire V, Holzgreve A, Albert NL, Nikulin P, Bachmann M, Kopka K, Krause M, Baumann M, Kazmierska J, Cegla P, Cholewinski W, Strouthos I, Zöphel K, Majchrzak E, Landry G, Belka C, Stromberger C, Hofheinz F. 18F-Fluorodeoxyglucose Positron Emission Tomography of Head and Neck Cancer: Location and HPV Specific Parameters for Potential Treatment Individualization. Front Oncol. 2022 Jun 8;12:870319. doi: 10.3389/fonc.2022.870319.

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Digital Poster

Comparison of Diffusion-weighted MRI using SPLICE and SS-EPI in Tumors of the Head and Neck.

Hedda J. van der Hulst 1,2 , Roland M. Martens 3,4 , Bram Westerink 1 , Loes Braun 1 , Leon ter Beek 5 , Jan W. Casselman 6 , Milad Ahmadian 1,7,8 , Zuhir Bodalal 1,2 , Renaud Tissier 9 , Regina G.H. Beets-Tan 1,2,10 , Michiel W.M. van den Brekel 7,11,12 , Jonas A. Castelijns 1 1 The Netherlands Cancer Institute, Department of Radiology, Amsterdam, Netherlands. 2 University of Maastricht, GROW School for Oncology and Developmental Biology, Maastricht, Netherlands. 3 Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam, Netherlands. 4 Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, Netherlands. 5 The Netherlands Cancer Institute, Department of Medical Physics, Amsterdam, Netherlands. 6 Dalhousie University Halifax, Department of Radiology, Nova Scotia, Canada. 7 The Netherlands Cancer Institute, Department of Head and Neck Oncology and Surgery, Amsterdam,