ESTRO 2024 - Abstract Book

S1400

Clinical - Head & neck

ESTRO 2024

Keywords: SGRT, open mask, patient movement

2424

Digital Poster

Photobiomodulation in head and neck cancer patients undergoing CRT: role in toxicities prevention

Margherita Rotondi 1 , Giuseppe Facondo 2 , Gabriela Dumitriescu 1 , Eric Deutsch 1,3 , Camelia Billard-Sandu 1

1 Gustave Roussy, Oncology-Radiotherapy, Villejuif, France. 2 Azienda Sanitaria Universitaria, Radiation Oncology, Udine, Italy. 3 INSERM, Radiothérapie Molèculaire et Innovation Thérapeutique, Villejuif, France

Purpose/Objective:

To evaluate the beneficial effect of photobiomodulation therapy (PBMT) in the prevention of toxicities induced by chemoradiotherapy (CRT) in head and neck cancer (HNC) patients.

Material/Methods:

Between May 2021 and May 2023 we retrospectively analyzed 80 patients (pts) with HNC treated with CRT in adjuvant or definitive intent, according to guidelines, and concomitant photobiomodulation (PBM). Two devices were used: ATP38, for external use (at 4 cm to the skin) composed of 3 LED screens connected to an articulated arm for greater mobility with different treatment protocols used based on the clinical indication (Tab.1). CareMin650 uses a luminous fabric composed of optical fibers and allows an intraoral use (via two flexible oral pads positioned inside the oral cavity) for oral mucositis (OM) in two times at each session and area. The median number of session was 10 (IQR, 7-13 sessions) and the population was divided into two groups: group A (PBM <10 sessions) 33 pts (41.25%), group B (PBM ≥10 sessions) 47 pts (58.75%). The main toxicities were assessed according to the CTCAE v5.0 at the half of PBMT (T1), at the end of PBMT (T2), during follow up at 3 months (T3) and at the last medical record (T4). It was considered also the weight loss between T2 and T0 (starting time of CRT) and T4-T0; the presence of periodontal disease G3 (presence of osteonecrosis) and dysphonia (excluding patients with laryngectomy) at T4. The chi- square test (or Fisher’s exact test, when appropriate) for ordinal variables was used to evaluate the association between PBM sessions and toxicity at different times. Logistic regression was used for continuous variables. Analysis of dependent variable “weight” was performed with a repeated -measures 2-way ANOVA with time of PBM (T0, T1, T2 and T4) and PBM sessions (<10 vs ≥10 sequences). The Kaplan– Meier method was used to estimate the rates survival analysis.