ESTRO 2024 - Abstract Book

S1405

Clinical - Head & neck

ESTRO 2024

Keywords: Oropharynx cancer, phase IV study

References:

1. Gillison ML, Trotti AM, Harris J et al. Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet. 2019;393(10166):40-50. 2. Mehanna H, Robinson M, Hartley A et al. De-ESCALaTE HPV Trial Group. Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet. 2019;393(10166):51-60. 3. Rischin D, King M, Kenny L et al. Randomized Trial of Radiation Therapy With Weekly Cisplatin or Cetuximab in Low-Risk HPV-Associated Oropharyngeal Cancer (TROG 12.01) - A Trans-Tasman Radiation Oncology Group Study. Int J Radiat Oncol Biol Phys. 2021;111(4):876-886.

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Digital Poster

Hospitalization and dose to Middle Constrictor and Parotid during CRT for Oropharynx Cancer

Jimmy Caudell, Jihye Koo, George Yang, Michelle Echevarria, Vladimir Feygelman

Moffitt Cancer Center, Radiation Oncology, Tampa, USA

Purpose/Objective:

Concurrent systemic therapy and radiation therapy (CRT) for locoregionally advanced oropharyngeal cancer can be an intense treatment, and hospitalization for adverse events is common. We sought to examine demographic, tumor, treatment, or dosimetric parameters that were prognostic for hospitalization during a course of CRT.

Material/Methods:

After IRB approval was obtained, a database of head and neck cancer patients treated with radiotherapy was queried. Patients treated with curative intent CRT for oropharyngeal squamous cell carcinoma were included. Demographic, tumor, and treatment factors as well as mean doses to delineated organs at risk from radiotherapy plans were abstracted from the chart and treatment planning systems. Hospitalization was defined as admission to hospital or stay in an emergency room/urgent care for > 24 hours during or within 90 days post treatment. Associations with categorical variables were tested via Fischer exact test and with continuous variables via independent samples T test. Potential prognostic factors for hospitalization were entered into a binary logistic regression multi-variable model.