ESTRO 2024 - Abstract Book

S1421

Clinical - Head & neck

ESTRO 2024

to interrogate target volumes and patterns of failure will help personalize management of oropharyngeal carcinoma.

Keywords: oropharyngeal SCC, contralateral nodal irradiation

References:

1. Grégoire, V. et al. Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 110, 172 – 181 (2014).

2. Welch, M et al. Computed Tomography Images from Large Head and Neck Cohort (RADCURE) (Version 1). doi:https://doi.org/10.7937/J47W-NM11.

3. Huang, S. H. et al. Re-evaluation of Ipsilateral Radiation for T1-T2N0-N2b Tonsil Carcinoma at the Princess Margaret Hospital in the Human Papillomavirus Era, 25 Years Later. Int. J. Radiat. Oncol. Biol. Phys. 98, 159 – 169 (2017).

2680

Digital Poster

Intensity modulated photon or proton therapy toxicity for oropharyngeal cancer: a systematic review

Mary Pat O' Sullivan, Annemarie Devine, Prof. Mark McEntee, Dr. Andrew England, Theresa O' Donovan

University College Cork, Medical Imaging and Radiation Therapy, School of Medicine, Cork, Ireland

Purpose/Objective:

The standard of care at present for OPSCC is definitive radiotherapy with or without chemotherapy 1,2 . Intensity modulated radiotherapy (IMRT) allows for increased target volume conformity within treatment plans 3 but low dose bath may exceed dose volume constraints (DVCs) of surrounding radiosensitive organs at risk (OARs) 4 , leading to a prevalence of acute and late toxicities for patients post treatment which have a debilitating effect on patient’s quality of life (QoL) 5 . Proton therapy is a contemporary advancement within the realm of radiotherapy cancer treatment 6 . The physical properties of protons facilitate a rapid dose fall off rate at depth and lacks exit dose referred to as the Bragg peak 7 . A lack of exit dose eliminates dose beyond the target to surrounding tissues 8 whilst maintaining target conformity 9 . The aim of this study is to comprehensively review available literature, compare toxicities and clinical outcomes experienced by patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with intensity modulated photon or proton radiation therapy (IMPT).

Material/Methods: