ESTRO 2024 - Abstract Book

S1565

Clinical - Lower GI

ESTRO 2024

In the colorectal cancer specific questionnaire (EORTC QLQ-CR29), 17% reported urinary incontinence, 45% of sexually active men reported erectile dysfunction and 30% of sexually active women reported dyspareunia.The mean score of urinary and digestive symptoms was 20.55 [0-100] and 4.99 [0-33.33] respectively.The mean global health status score was 60.1 [25-83.33]. This score was significantly worse in the group of patients with stoma 52.83 [25-83.33] versus 68.68 [50-83.33] in the group of patients without stoma (p=0.012).The body image mean score was 83.51 [0-100]. A negative body image was significantl associated with the presence of stoma (p=0.017).

Conclusion:

Urinary and sexual functions and the social embarrassment of the stoma were the main factors influencing the QoL of patients treated for rectal cancer with RAPIDO protocol. These challenges should be discussed with patients when presenting specific treatment modalities of colorectal cancer.

Keywords: rectal cancer, radiotherapy, quality of life

2992

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monocentric analysis of young rectal cancer patients treated with radio-chemotherapy treatment

Elisa Meldolesi 1 , Arianna Nicolì 1 , Giuditta Chiloiro 1 , Angela Romano 1 , Sergio Alfieri 2 , Roberto Persiani 2 , Claudio Coco 2 , Fabio Pacelli 2 , Stefania Manfrida 1 , Luca Boldrini 1 , Maria Antonietta Gambacorta 1 1 Policlinico Gemelli IRCCS, Radiation Oncology, Rome, Italy. 2 Policlinico Gemelli IRCCS, Abdominal Surgery, Rome, Italy

Purpose/Objective:

The current standard of care for rectal cancer patients defined by the European (ESMO) and American (NCCN) guidelines is not age-specific and literature on younger patients is still little and conflicting in results. To fill this gap in our knowledge, we investigated the impact of age and ESMO risk’s groups on clinical outcomes of young LARC patients treated in the last 15 years.

Material/Methods:

LARC patients undergoing NCRT at the Policlinico Universitario A. Gemelli, IRCCS followed by surgery were divided into young (<50/55 years) and old (>=50/55 years). 7th and 8th edition of the TNM was used for staging according to the diagnosis’ date (before or after December 2016). 2017 ESMO rectal cancer clinical practice guidelines were used to classify patients in different risk groups (very early, early, intermediate, bad, and advanced). All patients received neoadjuvant CRT treatment with long-course radiotherapy (50.4 - 60.1 Gy). The treatment was performed using a 3D conformal radiotherapy technique or IMRT. Surgical treatment was performed with TME, PME or, in rare cases, Hartmann surgery. In the case of local excision, TAMIS, TEM, TAE, have been used. Univariate and multivariate analysis were performed to identify predictive factors for OS, DFS, MFS and LC.