ESTRO 2024 - Abstract Book

S1582

Clinical - Lung

ESTRO 2024

Conclusion:

We devised a technique for quantifying morphometric complexity in NSCLC patients with IPF on radiotherapy and discovered lacunarity as a potential imaging biomarker for grade 3 or higher pneumonitis.

Keywords: radiotherapy, complication, imaging biomarker

96

Poster Discussion

Correlating lung dose and CT ventilation imaging-measured function with lung cancer patient survival

Jeremy Lim 1 , Hilary L Byrne 1 , John Kipritidis 2 , Paul J Keall 1 , Marcel van Herk 3

1 University of Sydney, Image X Institute, Sydney, Australia. 2 Royal North Shore Hospital, Northern Sydney Cancer Centre, Sydney, Australia. 3 University of Manchester, Radiotherapy Related Research, Division of Cancer Sciences, Manchester, United Kingdom

Purpose/Objective:

Radiotherapy treatment planning currently assumes that lung function is homogeneous, delivering radiation to the lung regardless of regional differences in function that may arise from tumour compression of lung structures or pre-existing factors such as chronic obstructive pulmonary disease and asbestos exposure. CT ventilation imaging (CTVI) has been developed as a more accessible alternative to nuclear medicine methods for mapping lung function as part of routine pre-treatment CT acquisition. Evidence shows that CTVI could deliver major health benefits, reducing the risk of severe radiation-induced lung injury in > 57,000 patients per year globally. 1-2 A study by Dupic et al. found that a mean lung dose (MLD) ≥ 5 Gy was significantly associated reduced OS in lung SABR. 3 The purpose of this work was to quantify the correlation between lung dose and CT ventilation imaging-measured function with lung cancer patient overall survival (OS).

Material/Methods: