ESTRO 2024 - Abstract Book

S163

Brachytherapy - Breast

ESTRO 2024

We analysed the association between OS and prognostic factors shown in Table 1. To highlight, there was a statistically significant association between the presence of pCR and higher rates of PFS and OS (Figure 1). No statistically significant differences were seen between the pCR versus partial response and the LC rate.

Toxicity: 9p and 2p presented G2 and G3 breast fibrosis, respectively. One case of late mastitis was noticed.

Conclusion:

Intensification with HDR-BT boost in patients with locally advanced breast cancer provides excellent local control rates, despite the presence of poor prognostic factors such as triple negative phenotype, high histological grade and/or the presence of residual disease after primary systemic treatment. HDR-BT boost could be considered for selected patients in this clinical scenario.

Keywords: Intensification, NACT, breast

References:

Preliminary Report of Partial-breast Irradiation Following Neoadjuvant Chemotherapy from COMBAT-NEO: Clinical Outcome of Multicatheter BrAchyTherapy after NEOadjuvant Chemotherapy