ESTRO 2024 - Abstract Book

S1700

Clinical - Lung

ESTRO 2024

were submitted to cTRT before starting maintenance IT with atezolizumab, while 16 received it also concomitantly. Only 3 pts who had undergone cTRT had to suspend maintenance IT due to toxicity (1 skin, 1 pneumonitis and 1 unknown). Regarding overall toxicity, In total, 39 of 103 pts (37,8%) experienced toxicity >grade 2 which was: hematological in 27 (26.2%), pulmonary in 10 (9.7%) and gastrointestinal in 8 (7.7%) pts. No excess of GI or pulmonary toxicity (3 of 33 pts) was found in the cTRT subgroup (only 1 G5 pneumonitis). Median OS and PFS were 14.2 and 7.1 months, respectively.

Conclusion:

Consolidative TRT combined with CT-IT showed a good toxicity profile, proving to be feasible and safe also in a large “real life” setting. Clinical outcome is positive. Prospective trials are needed to confirm feasibility,correct timing and clinical impact of cTRT on local disease control and survival.

Keywords: SCLC, consolidative RT, chemoimmuinotherapy

1873

Digital Poster

CT-based radiomics and respiratory function in patients receiving lung RT: an exploratory analysis

Mattia Zaffaroni 1 , Stefania Volpe 1 , Maria Giulia Vincini 1 , Alice Porazzi 2 , Vanessa Pierini 1 , Lucrezia Berton 2 , Sabrina Clobiaco 1 , Gaia Piperno 1 , Maria Alessia Zerella 1 , Federica Cattani 3 , Barbara Alicja Jereczek-Fossa 1 1 IEO, European Institute of oncology, IRCCS, Division of radiation oncology, Milan, Italy. 2 University of Milan, Biomedical omics, Milan, Italy. 3 IEO, European Institute of oncology, IRCCS, Unit of Medical Physics, Milan, Italy

Purpose/Objective:

The interest in radiomics has been growing exponentially in the last years. Its potential relies into the extraction of non-invasive and reproducible quantitative imaging features which may yield mineable information for clinical practice implementation. Quantification of baseline lung functionality through radiomic analysis could play a pivotal role in the patients’ management, both for diagnostic and curative intents. Aim of this study is to identify non invasive quantitative biomarkers of respiratory functions by investigating the association between radiomic features and pulmonary function parameters, with a dedicated focus on the diffusing capacity of the lungs for carbon monoxide (DLCO).

Material/Methods:

Eligibility criteria were as follows: (i) lung disease of either primary origin or oligometastatic lung disease from any primary site (ii) availability of 4D-simulation computed tomography (CT) scans; (iii) availability of baseline spirometry data with diffusing capacity of the lungs for carbon monoxide (DLCO) values; (iv) availability of written informed