ESTRO 2024 - Abstract Book

S1710

Clinical - Lung

ESTRO 2024

Prognostic factors for distant metastases were: histological favourable subtypes (5-year DMFS of 92% vs. 51% for unfavourable; p = 0.015); Masaoka-Koga stage II (5-year DMFS of 92% vs. 40% for stages III-IV; p = 0.001) and R0 margin status (5-year DMFS of 90% vs. 20% for R1-2; p = 0.01).

Histological subtype B3 was associated with death from thymoma (p = 0.008). Ten percent of patients died of thymoma.

The most common acute toxicities were oesophagitis (grade 2) in 2 patients (6%) and epithelitis (grade 2) in 7 patients (23%). The most common late toxicity was pulmonary fibrosis (grade 2) in 2 patients (6%), but none of these were grade ≥ 3.

Conclusion:

In our experience, PORT for thymoma provides a significant benefit in OS and local control. WHO subtype, Masaoka Koga stage and margin status were good predictors of risk of recurrence and distant metastases. Systemic treatment should be considered in patients with high-risk features.

Keywords: thymoma, postoperative radiotherapy,

References:

1. Gatta G, Capocaccia R, Botta L, Mallone S, De Angelis R, Ardanaz E, et al. Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet-a population-based study. Lancet Oncol. 2017;18:1022 – 39.doi.org/10.1016/S1470- 2045(17)30445-X. 2. Girard N, Ruffini E, Marx A, Faivre-Finn C, Peters S. Thymic epithelial tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2015;26:v40-v55. doi:10.1093/annonc/mdv277