ESTRO 2024 - Abstract Book

S1734

Clinical - Lung

ESTRO 2024

radiotherapy in the treatment of EGFR mutant lung adenocarcinoma with craniocerebral metastasis was emphasized.In the low score group of Lung-molGPA that patients with worse clinical conditions, should be given EGFR-TKIs-based systematic treatment.In patients with high Lung-molGPA score and better clinical condition, according to the results of analysis, craniocerebral radiotherapy as early as possible can prolong survival.

Keywords: EGFR-mutant, Lung adenocarcinoma, Brain metastasis

References:

1.Deng G, Zhang Y, Ke J, Wang Q, Qin H, Li J, et al. Effect of brain radiotherapy

strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with

brain metastasis. J Transl Med 2021;7:503. https://doi.org/10.1186/s12967-021-

03161-1.

2.Deng G, Tan X, Li Y, et al. Effect of EGFR-TKIs combined with craniocerebral radiotherapy on the prognosis of EGFR-mutant lung adenocarcinoma patients with brain metastasis: A propensity-score matched analysis. Front Oncol. 2023;13:1049855. Published 2023 Feb 9. doi:10.3389/fonc.2023.1049

2334

Poster Discussion

Can real-world data be used to assess toxicity of lung radiotherapy? A data quality audit.

Harry Frederick Crawford 1 , Rebecca Holley 2 , Danya Abdulwahid 3 , Kathryn Banfill 3 , Claire Barker 3 , Neil Bayman 3 , Clara Chan 3 , Joanna Coote 3 , Margaret Harris 3 , Jennifer King 3 , Tom Marchant 4,2 , Catharine Morgan 5 , Laura Pemberton 3 , Hamid Sheikh 3 , David Kenneth Woolf 3 , Corinne Faivre-Finn 2,3 , Gareth Price 2,4 1 The Christie NHS Foundation Trust, Lung Research Team, Department of Research and Development, Manchester, United Kingdom. 2 The University of Manchester, Division of Cancer Sciences, Manchester, United Kingdom. 3 The Christie NHS Foundation Trust, Department of Clinical Oncology, Manchester, United Kingdom. 4 The Christie NHS Foundation Trust, Department of Medical Physics, Manchester, United Kingdom. 5 The University of Manchester, Division of Informatics, Imaging & Data Sciences, Manchester, United Kingdom

Purpose/Objective:

Pragmatic studies using data collected during a patient’s normal course of treatment (real world data -RWD) has the potential to significantly reduce extra clinic visits, improve inclusivity, and reduce costs when compared to randomised controlled trials (RCT). However, for RWD to have an impact on clinical practice, the data collected must be of high quality.