ESTRO 2024 - Abstract Book

S1736

Clinical - Lung

ESTRO 2024

Toxicity according to CTCAE

Grade

N

(before

N (after corrections) % (after corrections)

corrections)

Oesophagitis Oesophagitis Pneumonitis Pneumonitis Pneumonitis Pneumonitis

2 3 2 3 4 5

18

111

31.9 0.86 2.01 0.86 0.57 0.29

0 6 1 0 0

3 7 3 2 1

Conclusion:

Data quality of recorded toxicities following radiotherapy for lung cancer was reviewed at our centre. Good quality data was found for 61% of patients, but manual review of patient notes or further patient contact was required for the remaining cases. The use of a rigorous algorithm for reviewing patient notes manually ensures the consistency of data recorded. However, since symptoms associated with radiation pneumonitis are not specific there is a risk of under/over-reporting of such side effects. Improving the quality of available toxicity data is vital to the successful use of real-world data to drive improvements in radiotherapy.

Keywords: oesophagitis, pneumonitis, toxicity

References:

[1] G. Price et al., “Can Real -world Data and Rapid Learning Drive Improvements in Lung Cancer Survival? The RAPID RT Study,” Clin Oncol, vol. 34, no. 6, pp. 407– 410, Jun. 2022, doi: 10.1016/j.clon.2021.12.017.

2381

Mini-Oral

Inhomogeneous dose escalation for NSCLC: Full dosimetric analysis of the phase III NARLAL2 trial

Christina M Lutz 1 , Tine B Nielsen 2 , Mikkel D Lund 3 , Tine Schytte 2 , Torben S Hansen 3 , Lone Hoffmann 1,4 , Katarina W Ottosson 5 , Cécile Peucelle 6 , Espen Rusten 7 , Nina Levin 8 , Carsten Brink 2 , Bjørn H Grønberg 8,9 , Vilde D Haakensen 7 , Olfred Hansen 2 , Azza A Khalil 1,4 , Marianne M Knap 1 , Charlotte Kristiansen 3 , Morten Nielsen 2 , Gitte F Persson 5,10 , Mette Pøhl 6 , Rune S Thing 3 , Ditte S Møller 1,4 1 Aarhus University Hospital, Department of Oncology, Aarhus, Denmark. 2 Odense University Hospital, Department of Oncology, Odense, Denmark. 3 Vejle Hospital, University Hospital of Southern Denmark, Department of Oncology, Vejle, Denmark. 4 Aarhus University, Department of Clinical Medicine, Aarhus, Denmark. 5 Copenhagen University Hospital Herlev and Gentofte, Department of Oncology, Herlev, Denmark. 6 Rigshospitalet, Department of Oncology, Copenhagen, Denmark. 7 Oslo University Hospital, Department of Oncology, Oslo, Norway. 8 St. Olavs hospital, Department of Oncology, Trondheim, Norway. 9 Norwegian University of Science and Technology, Department of