ESTRO 2024 - Abstract Book

S1756

Clinical - Lung

ESTRO 2024

Patients having at the same time the three structures above the population 3rd quartile have an OS2 of 73% (11 deaths over 15 patients). On the other side, for the group of patients with values below the 1st quartile in the distribution, the rate was 30% with 3 events over 10 patients.

Conclusion:

Our random forest model highlighted the importance of HSs and lung tissue interaction, as suggested by the literature [2]. Sequential CH-RT leads to worse outcomes following other studies [3]. After including risk factors from patients' comorbidity and the presence of cardiac calcifications, such models could identify dose tolerance for the most radiosensitive, improving the success rate of RT or CH-RT for LA-NSCLC patients, which is currently limited by adverse events.

The development of a survival model, including the dosimetric information from HSs, can drive the clinical practice toward a safe dose escalation protocol, exploiting the current technological level of the RT at best.

Keywords: overall survival, adverse events, cardiac toxicity

References:

1) Banfill K, Giuliani M, Aznar M et al. Cardiac Toxicity of Thoracic Radiotherapy: Existing Evidence and Future Directions. J Thorac Oncol. 2021 Feb;16(2):216-227. doi: 10.1016/j.jtho.2020.11.002