ESTRO 2024 - Abstract Book

S1781

Clinical - Lung

ESTRO 2024

Data from 5,042 patient with lung cancer with available age, sex, performance status, date of symptoms onset, date of diagnosis, and cancer type were collected between 2010 and 2022. Information on patient-reported symptom onset and clinical factors was obtained from health care records. To mitigate registration errors, intervals shorter than 14 days and longer than 365 days were considered unrealistic and excluded. Seven domains representing multiple deprivation factors, such as education, income, employment, health, crime, environment, and housing, were collected and categorized into three levels: high, medium, and low. Due to the high interrelation between these domains, they were tested individually in the model together with relevant priori factors. A general linear model was employed to explore potential disparities in diagnosis stage, lung cancer type, and various socioeconomic domains affecting the diagnostic interval time.

Results:

The analysis included 4,508 lung cancer patients with a diagnostic interval time between 2 weeks and 1 year. Among all lung cancer patients, the median age was 71 years (range 29 to 96), with 52% being male, and 3,612 had non small cell lung cancer (NSCLC) while 896 had small cell lung cancer (SCLC). The median diagnostic interval times for NSCLC and SCLC were 64 days (range 15 to 364) and 58 days (range 15 to 358), respectively. 3,148 (70%) of the patients received radiotherapy as part of their treatment. For radiotherapy treated patients, the median diagnostic interval times for NSCLC and SCLC were 64 days (range 15 to 364) and 62 days (range 15 to 358), respectively. Multivariable linear regressions for both the full cohort and radiotherapy cohort yielded consistent results for medium income and stage as follow 1) there were significantly shorter intervals for those with medium income compared to those with low income; 2) there were also significantly shorter intervals for those with high level of health; 3) a prolonged time interval correlated with an elevated risk of being diagnosed with loco-regional and distant disease, as opposed to local disease; 4) SCLC patients had a shorter time interval 5) no significant differences were observed based on the patients' sex or age (Figure 1 and 2).