ESTRO 2024 - Abstract Book

S176

Brachytherapy - GI, paediatric, miscellaneous

ESTRO 2024

Keywords: Autoradiography, Alpha, Colorectal Adenocarcinoma

References:

[1] L. Arazi, T. Cooks, M. Schmidt, et al. , "Treatment of solid tumors by interstitial release of recoiling short-lived alpha emitters", Physics in Medicine and Biology , vol. 52, pp. 5025-5042, 2007.

[2] T. Cooks, L. Arazi, M. Schmidt, et al., "Growth retardation and destruction of experimental squamous cell carcinoma by interstitial radioactive wires releasing diffusing alpha-emitting atoms", International Journal of Cancer , vol. 122, pp. 1657-1664, 2007.

[3] L. Arazi, T. Cooks, M. Schmidt, et al. , "The treatment of solid tumors by alpha emitters released from 224-Ra loaded sources - Internal dosimetry analysis", Physics in Medicine and Biology , vol. 55, pp. 1203-1218, 2010.

[4] L. Arazi, T. Cooks, M. Schmidt, et al., "Alpha DaRT: Revolutionary alpha-emitters brachytherapy", Journal of Medical Imaging and Radiation Sciences, vol. 50, no.4, pp. S96-S97, 2019.

[5] T. Cooks, M. Schmidt, H. Bittan, et al., "Local control of lung derived tumors by diffusing alpha-emitting atoms released from intratumoral wires loaded with radium-224", International Journal Radiation Oncology Biological Physics, vol. 74, no.3, pp. 966-973, 2009. [6] T. Cooks, L. Arazi, M. Efrati, et al. , "Interstitial wires releasing diffusing alpha emitters combined with chemotherapy improved local tumor control and survival in squamous cell carcinoma-bearing mice", American Cancer Society , vol. 115, pp. 1791-1801, 2009.

[7] T. Cooks, M. Tal, S. Raab, et al. , "Intratumoral 224Ra-loaded wires spread alpha-emitters inside solid human tumors in athymic mice achieving tumor control", Anticancer Research , vol. 32, pp. 5315-5322, 2012.

[8] L. Arazi, "Thesis; Diffusing alpha-emitters radiation therapy: theoretical and experimental dosimetry", Tel-Aviv University, School of Physics and Astronomy, pp. 1-285, 2008.

608

Digital Poster

Improving timely MRI-based brachytherapy treatment delivery in rectal cancer

Rahul Krishnatry 1,2 , Manideep Peddi 1,2 , Akshay Dineshan 1,2 , Shivakumar Gudi 1,2 , Reena Engineer 1,2

1 Tata Memorial centre, Radiation Oncology, Mumbai, India. 2 HBNI, University, MUMBAI, India

Purpose/Objective:

The long-course chemoradiation followed by brachytherapy boost is one of the acceptable treatment options for wait-and-watch-eligible rectal cancer patients. Routine non-availability of MRI in the radiation department, along with other logistic factors, can delay the planning and delivery process in MRI-based brachytherapy. These delays lead to dissatisfaction among the patients and the treating team. In this study, we describe the optimisation of