ESTRO 2024 - Abstract Book

S179

Brachytherapy - GI, paediatric, miscellaneous

ESTRO 2024

Keywords: MRI brachytherapy, Rectum, Quality improvement

References:

Manjali JJ et al. JCO Glob Oncol. 2022 Aug;8:e2100367. doi: 10.1200/GO.21.00367.

Engineer R et al. Indian J Surg Oncol. 2021 Dec;12(4):664-670. doi: 10.1007/s13193-021-01421-6.

1340

Proffered Paper

Timing of Contact X-ray Brachytherapy in organ-preserving treatment of small rectal cancer

Ngu Wah Than 1,2 , David Mark Pritchard 1 , Carrie Duckworth 1 , David Hughes 3 , Sun Myint 2,1

1 University of Liverpool, Department of Molecular and Clinical Cancer Medicine, Liverpool, United Kingdom. 2 Clatterbridge Cancer Centre, Papillon Barchytherapy Suite, Liverpool, United Kingdom. 3 University of Liverpool, Department of Health Data Science, Liverpool, United Kingdom

Purpose/Objective:

For patients with early rectal cancer, who are either at high risk for or refuse surgery, a planned organ preservation treatment involving a combination of external beam radiotherapy (EBRT) and Contact X-ray Brachytherapy (CXB) can be offered as an alternative option to surgery. (1-3) However, the ideal sequence of treatment for small rectal tumours (≤3cm), whether to administer CXB first or after EBRT, has not yet been well established, leading to variable sequences of this organ-preserving treatment being used.(3-5) This study has compared the oncological outcomes between the two treatment approaches using propensity score matching and inverse probability treatment weighting (IPTW) analysis to evaluate whether starting with CXB confers any benefits to patients.

Material/Methods: