ESTRO 2024 - Abstract Book

S1889

Clinical - Mixed sites, palliation

ESTRO 2024

reported in larger cohorts to assess safety of combined 5-FU based chemoradiotherapy protocols in this group of patients.

Keywords: DPYD deficiency, chemoradiotherapy

References:

[1] Barin-Le Guellec C, Lafay-Chebassier C, Ingrand I et al.: Toxicities Associated With Chemotherapy Regimens Containing a Fluoropyrimidine: A Real-Life Evaluation in France. Eur J Cancer 124:37-46, 2020. DOI: 10.1016/j.ejca.2019.09.028

[2] https://www.ema.europa.eu/en/documents/referral/fluorouracil-fluorouracil-related-substances-article-31 referral-ema-recommendations-dpd-testing_en.pdf

[3] Positionspapier der DGHO: Dihydropyrimidin-Dehydrogenase (DPD) -Testung vor Einsatz von 5-Fluorouracil, Capecitabin und Tegafur, 06/2020

1071

Poster Discussion

Prospective trial on CBCT imaging with 2D antiscatter grid: initial experience with image quality

Cem Altunbas, Farhang Bayat, Ryan Sabounchi, Uttam Pyakurel, Roy Bliley, Mallory Olberding, Kelsey Leverty, Moyed Miften, Ryan Lanning, Christine Fisher, Rachel Rabinovitch, David Binder, Brian Kavanagh, Tyler Robin

University of Colorado, Radiation Oncology, AURORA, USA

Purpose/Objective:

Poor CBCT image quality is one of the major detriments during target localization and for quantitative dose delivery monitoring using CBCT images. Scattered radiation is one of the major causes of poor CBCT image quality. To suppress scatter and improve CBCT image quality, we developed novel two-dimensional (2D) anti-scatter grid and data correction algorithms for linac-mounted CBCT systems. In this work, we present the first image quality assessment of our proposed CBCT approach in an ongoing prospective trial.

Material/Methods:

Our proposed CBCT approach was referred to as quantitative CBCT (qCBCT). Each qCBCT scan was acquired by installing an internally developed tungsten 2D antiscatter grid prototype on the kV imaging panel (Fig. 1). Raw images were corrected for residual scatter that was not rejected by the 2D grid. An Institutional Review Board (IRB)- approved imaging protocol was developed to evaluate the efficacy of the qCBCT method. Each trial participant was