ESTRO 2024 - Abstract Book

S1894

Clinical - Mixed sites, palliation

ESTRO 2024

fraction schedule. Due to the poor survival in this group of patients, a single fraction schedule should be recommended in future patients with bone metastases from upper GI-cancer.

The most common fractionation schedule includes the prescriptions of 4-5 fractions in our institution. However, there is only a small difference in OS between patients receiving a single fraction, compared to patients that receive 4-5 fractions. This finding calls for more focus on patient selection for single fraction versus fractionated RT, because patients with a short life expectancy should be offered a treatment schedule with a limited number of hospital visits. In case of recurrent bone pain, a single fraction schedule can be repeated without significant risk of side effects.

Overall, there are no significant differences in survival between young and elderly patients receiving palliative RT for bone metastases. Age itself should therefore not be the deciding factor in the choice of fractionation schedule.

The clinician’s choice of fractionation schedule in future patients should include considerations regarding the patients´ life expectancy in relation to cancer type, comorbidity, location, and tumour biology, as well as cost effectiveness.

Keywords: Bone metastases, palliative radiotherapy

1112

Poster Discussion

VMAT Stereotactic Radiosurgery: Efficacy and Safety Data of a Phase I Prospective Trial (DESTROY-2)

Francesco Deodato 1,2 , Savino Cilla 3 , Donato Pezzulla 1 , Mariangela Boccardi 1 , Vincenzo Picardi 1 , Carmela Romano 4 , Alice Zamagni 5 , Silvia Cammelli 5 , Milly Buwenge 5 , Alessio Giuseppe Morganti 5 , Gabriella Macchia 1 1 Responsible Research Hospital, Radiation Oncology Unit, Campobasso, Italy. 2 Università Cattolica del Sacro Cuore, Istituto di Radiologia, Roma, Italy. 3 Responsible Research Hospital, Medical physics Unit, Campobasso, Italy. 4 Responsible Research Hospital, Medical Physics Unit, Campobasso, Italy. 5 IRCCS Azienda Ospedaliero, Universitaria di Bologna - Alma Mater Studiorum University of Bologna, Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Bologna, Italy

Purpose/Objective:

To present the final results of a phase I trial on stereotactic radiosurgery (SRS) delivered using volumetric modulated arc therapy (VMAT) in patients with primary or metastatic tumours in different extracranial sites.

Material/Methods:

The DESTROY-2 trial, planned as a prospective dose escalation study in oligometastatic (one to five lesions) cancer patients, relied on the delivery of a single high dose of radiation utilizing high-precision technology1. All patients