ESTRO 2024 - Abstract Book

S1905

Clinical - Mixed sites, palliation

ESTRO 2024

EQ-5D-5L Quality-of-life health profiles for each dimension were stable or slightly improved by 6 months, and differences were not significant between the groups. The EQ VAS score improved from a mean of 61.2 (SD 20.5) at the baseline to 64.3 (SD 14.7) at 6 months in the SBRT group vs. 61.3 (19.7) and 63.9 (SD 22.7) in the cEBRT group, respectively (P=0.94).

Conclusion:

Dose-intensified SBRT effectively and safely improved pain in patients with painful spinal metastases. Further investigations on optimizing patient selection, radiation dose and fractionation are warranted.

Keywords: Painful spinal metastases, SBRT, cEBRT

References:

Acknowledgment: This project was supported by the grant KFS-3956-08-2016-R of Swiss Cancer Research and Varian, a Siemens Healthineers company.

1194

Digital Poster

Clinical indications for carbon-ion radiotherapy in the UK: A systematic review

Ellie Light, Pete Bridge

University of Liverpool, School of Health Sciences, Liverpool, United Kingdom

Purpose/Objective:

Carbon-ion radiotherapy (CIRT) has unique radiobiological properties1 that cause increased radiobiological effect and tumour control, especially with hypoxic tissues2. Carbon ions exhibit up to 10 times higher linear energy transfer (LET) and relative biological effect (RBE) than protons and thus offer the potential for improved tumour control3. In addition, carbon ions have a relatively low LET in the entrance channel, which minimises normal tissue irradiation and could reduce incidence of toxicities2. Moreover, distal tissues receive little energy, unlike protons, allowing for better sparing of organs at risk (OARs). A recent article4 proposed establishing a CIRT centre in the UK, but lacked clinical evidence relating to the potential impact of this. This systematic review aimed to evaluate clinical response to CIRT across all published tumour sites to establish any clinical need for a CIRT centre in the UK.

Material/Methods:

A systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Literature searching was undertaken in November 2022 within the PubMed, Science Direct,