ESTRO 2024 - Abstract Book

S185

Brachytherapy - GI, paediatric, miscellaneous

ESTRO 2024

radiotherapy (POIRT) as an adjuvant treatment. The aim of our work is to report the results involving POIRT approach in a homogenous cohort of patients affected by keloid and treated at a single institution with the same fractionation schedule.

Material/Methods:

Inclusion criteria were as following: 1) surgery with a histopathological diagnosis of keloid, 2) subsequent high dose rate interventional radiotherapy (HDR-IRT) with prescription dose to clinical target volume of 12 Gy in 4 fractions (3 Gy/fr) administered twice a day with at least 6 hours between, 3) follow-up period of at least 24 months.

Results:

One-hundred and two patients and a total of 135 keloids were eligible for the analyses. The median follow-up was 64 [interquartile range: 25 - 103] months. In our cohort 36 (26.7%) recurrences were observed, 12-months and 36 months cumulative incidence of recurrence were 20.7% (95% CI: 12.2 - 28.5) and 23.8% (95% CI: 14.9 - 31.7) respectively. History of spontaneous keloids (HR=7.00, 95% CI: 2.79 -17.6, p < 0.001), spontaneous cheloid as keloid cause (HR=6.97, 95% CI: 2.05 - 23.7, p = 0.002) and sternal (HR=10.6, 95% CI: 3.08 - 36.8, p < 0.001), ear (HR=6.03, 95% CI: 1.71 - 21.3, p = 0.005) or limb (HR=18.8, 95% CI: 5.14 - 68.7, p < 0.001) keloid sites were significantly associated to a higher risk of recurrence.

Conclusion:

The findings support the use of surgery and POIRT as an effective strategy for controlling keloid relapses. Further studies are needed to identify the optimal Biologically Effective Dose (BED) for keloid treatment and to establish a scoring system for patient selection for surgery and radiotherapy.

Keywords: keloids, brachytherapy, surgery

2184

Digital Poster

HDR-IBT in unfavourable primary and secondary liver malignancies

Syadwa Abdul Shukor 1 , Yiat Horng Leong 1 , Keerthaanaa Yogabalan 2 , Fitreena Anis Amran 2 , Gokula Kumar Appalanaido 2 1 National University Cancer Institute Singapore, Radiation Oncology, Singapore, Singapore. 2 Advanced Medical & Dental Institute, Universiti Sains Malaysia, Radiation Oncology, Penang, Malaysia

Purpose/Objective:

To evaluate the safety and clinical outcome of high dose rate interstitial brachytherapy (HDR-IBT) in the treatment of large primary and secondary liver malignancy.